Quantification of the relative contribution of environmental and genetic factors to variation in cystic fibrosis lung function.
Quantification of the relative contribution of environmental and genetic factors to variation in cystic fibrosis lung function.
复制标题
DOI：
10.1016/j.jpeds.2010.05.018
复制
发表时间：
2010-11
影响因子：
5.1
通讯作者：
Cutting, Garry R.
中科院分区：
文献类型：
--
作者：
Collaco, J. Michael;Blackman, Scott M.;McGready, John;Naughton, Kathleen M.;Cutting, Garry R.
评估环境和遗传因素对囊性纤维化（CF）肺病变异的相对贡献。使用134例单卵双胞胎和272例双卵双胞胎和兄弟姐妹在不同生活环境中（即与父母一起生活与单独生活）的CF特异性FEV1测量的配对内相关性和差异以及使用80名兄弟姐妹的肺功能的个体内差异来量化遗传和环境贡献。无论生活环境如何，单卵双胞胎之间的肺功能比双卵双胞胎和兄弟姐妹之间更相似，这肯定了遗传修饰剂在CF肺功能中的作用。回归模型显示，遗传因素占肺功能变化的50%，独特的环境和随机因素占36%，共有的环境因素占14%（模型p：<0.0001）。个体内部分析对独特和共享环境的贡献产生了类似的估计。共享环境的影响主要是由于与患有CF的兄弟姐妹一起生活（p：0.003），而不是父母家庭内的因素（p：0.310）。遗传和环境因素对CF的肺功能变化同样有影响。环境效应主要是由独特的和随机的影响，而不是共同的曝光。
To assess the relative contributions of environmental and genetic factors to variation in cystic fibrosis (CF) pulmonary disease. Genetic and environmental contributions were quantified using intra-pair correlations and differences in CF-specific FEV1 measures from 134 monozygous twins and 272 dizygous twins and siblings while in different living environments (i.e. living with parents vs. living alone) as well as using intra-individual differences in lung function from a separate group of 80 siblings. Lung function among monozygous twins was more similar than among dizygous twin and sibling pairs, regardless of living environment, affirming the role of genetic modifiers in CF lung function. Regression modeling revealed that genetic factors account for 50% of lung function variation, unique environmental and stochastic factors 36%, and shared environmental factors, 14% (Model p: <0.0001). The intra-individual analysis produced similar estimates for the contributions of the unique and shared environment. The shared environment effects appeared primarily due to living with a sibling with CF (p: 0.003), rather than factors within the parental household (p: 0.310). Genetic and environmental factors contribute equally to lung function variation in CF. Environmental effects are dominated by unique and stochastic effects rather than common exposures.
登录
查看更多内容
影响因子：
5.1
作者：
Schechter, MS;Margolis, PA
通讯作者：
Margolis, PA
DOI：
10.1164/ajrccm.163.6.9912100
发表时间：
2001-05-01
影响因子：
24.7
作者：
Schechter, MS;Shelton, BJ;Fitzsimmons, SC
通讯作者：
Fitzsimmons, SC
影响因子：
158.5
作者：
RUBIN, BK
通讯作者：
RUBIN, BK
影响因子：
158.5
作者：
KEREM, E;COREY, M;DURIE, P
通讯作者：
DURIE, P
DOI：
10.1073/pnas.0308479101
发表时间：
2004-03-09
影响因子：
11.1
作者：
Wexler, NS
通讯作者：
Wexler, NS