Neurobiology of Photophobia
Neurobiology of Photophobia
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DOI：
10.1097/wno.0000000000000766
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发表时间：
2019-03-01
影响因子：
2.9
通讯作者：
Fulton, Anne B.
中科院分区：
文献类型：
--
作者：
Burstein, Rami;Noseda, Rodrigo;Fulton, Anne B.
背景：畏光通常与偏头痛、脑膜炎、脑震荡和多种眼部疾病有关。在我们的能力，以跟踪多个大脑通路，通过光信息的处理铺平了道路，以更好地了解神经生物学的恐惧症和复杂的症状所引发的light.Purpose：本综述的目的是总结最近的解剖和生理研究神经生物学的恐惧症，重点偏头痛。在失明和视力正常的偏头痛患者以及各种动物模型中进行的观察发现了一种新的视网膜-丘脑皮质通路，该通路将来自黑视素能和非黑视素能视网膜神经节细胞（RGC）的光信号传递到丘脑神经元。这些神经元的活动由偏头痛驱动，并且它们的轴突投射将关于头痛和光的信号传递到参与产生常见偏头痛症状的多个皮质区域。还发现了RGCs向先前未鉴定的调节副交感神经和交感神经功能的下丘脑神经元的新投射。最后，最近的工作已经导致了一个新的理解偏头痛型的颜色偏好和视网膜，丘脑和cortex.Summary所扮演的角色：研究结果提供了一个神经基板了解偏头痛和神经眼科其他疾病患者的复杂性厌恶光。(C)2019年由北美神经眼科学会麻醉和重症监护部（RB，RN），贝斯以色列
Background: Photophobia is commonly associated with migraine, meningitis, concussion, and a variety of ocular diseases. Advances in our ability to trace multiple brain pathways through which light information is processed have paved the way to a better understanding of the neurobiology of photophobia and the complexity of the symptoms triggered by light.Purpose: The purpose of this review is to summarize recent anatomical and physiological studies on the neurobiology of photophobia with emphasis on migraine.Recent Findings: Observations made in blind and seeing migraine patients, and in a variety of animal models, have led to the discovery of a novel retino-thalamocortical pathway that carries photic signal from melanopsinergic and nonmelanopsinergic retinal ganglion cells (RGCs) to thalamic neurons. Activity of these neurons is driven by migraine and their axonal projections convey signals about headache and light to multiple cortical areas involved in the generation of common migraine symptoms. Novel projections of RGCs into previously unidentified hypothalamic neurons that regulate parasympathetic and sympathetic functions have also been discovered. Finally, recent work has led to a novel understanding of color preference in migrainetype photophobia and of the roles played by the retina, thalamus, and cortex.Summary: The findings provide a neural substrate for understanding the complexity of aversion to light in patients with migraine and neuro-ophthalmologic other disorders. (C) 2019 by North American Neuro-Ophthalmology Society Department of Anesthesia and Critical Care (RB, RN), Beth Israel