Molecular biology of septic shock.
Molecular biology of septic shock.
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发表时间：
1998-05
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通讯作者：
K. Murphy;S. Haudek;M. Thompson;B. Giroir
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作者：
K. Murphy;S. Haudek;M. Thompson;B. Giroir
Septic shock is a complex pathophysiologic state which often leads to multiple organ dysfunction, multiple organ failure, and death. This review summarizes current views on the molecular biology of three aspects of septic shock: recognition of bacterial invasion and induction of the cytokine response; genetic variability among humans and their predispositions toward pathologic inflammatory responses; and the signal transduction mechanisms which account for the transfer of molecular signals from cytokine receptors on the plasma membrane to cytokine-responsive genes in the nucleus. In particular, the review summarizes the pathway involved in tumor necrosis factor signaling through nuclear factor-kappaB, and elucidates the molecular signals involved in inflammatory responses and apoptosis.
