Correlation between the Serum Pepsinogen I Level and the Symptom Degree in Proton Pump Inhibitor-Users Administered with a Probiotic.
Correlation between the Serum Pepsinogen I Level and the Symptom Degree in Proton Pump Inhibitor-Users Administered with a Probiotic.
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DOI：
10.3390/ph7070754
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发表时间：
2014-06-25
期刊：
影响因子：
--
通讯作者：
Koga Y
中科院分区：
文献类型：
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作者：
Igarashi M;Nagano J;Tsuda A;Suzuki T;Koike J;Uchida T;Matsushima M;Mine T;Koga Y
在胃食道反流病和功能性消化不良等功能性上消化道疾病的患者中，症状的出现被认为是在没有任何器质性疾病的情况下发生的，其背后的机制尚不清楚。因此，我们研究了胃相关生物标记物水平和症状之间的关系。24名每天服用质子泵抑制剂的门诊患者参加了这项研究。受试者连续三个月每天饮用含有109个发酵乳杆菌OLL2716(LG21)菌落形成单位的酸奶。他们总共接受了四次临床检查。每项检查包括回答一份带有GERD症状频率量表(FSSG)的问卷，并测量血清胃泌素、Ghrelin和胃蛋白酶原I和II的水平。结果显示，在未进行年龄调整的情况下，LG21治疗后FSSG评分和PGI值分别呈下降和上升趋势。对性别和年龄进行额外调整的多元回归分析显示，PGI值和FSSG症状评分之间存在很强的相关性。因此，这些症状的病因可能与PGI水平本身或调节PGI水平的因素有关。
In patients with functional upper gastrointestinal disorders such as gastroesophageal reflux disease and functional dyspepsia, the presence of symptoms is thought to occur in the absence of any organic diseases and the mechanisms behind this remain unclear. We therefore examined the relationship between stomach-related biomarker levels and symptoms. Twenty-four outpatients who had taken proton-pump inhibitors every day were enrolled in this study. The subjects consumed yogurt containing 109 colony-forming units of Lactobacillus gasseri OLL2716 (LG21) every day for three months. They underwent four clinical examinations in total. Each examination consisted of answering a questionnaire with a frequency scale for the symptoms of GERD (FSSG), and included measurements of the serum gastrin, ghrelin, and pepsinogens I and II levels. As a result, the FSSG score and the PGI value showed a decrease and an increase, respectively, after LG21 treatment when analyzed without age adjustment. A multiple regression analysis with additional adjustments for gender and age revealed a strong association between the PGI value and the FSSG symptom scores. Therefore either the PGI level itself or the factors regulating the PGI level might be involved in the etiology of these symptoms.