Prothoracicotropic hormone regulates developmental timing and body size in Drosophila
Prothoracicotropic hormone regulates developmental timing and body size in Drosophila
复制标题
DOI：
10.1016/j.devcel.2007.11.003
复制
发表时间：
2007-12-01
影响因子：
11.8
通讯作者：
O'Connor, Michael B.
中科院分区：
文献类型：
--
作者：
McBrayer, Zofeyah;Ono, Hajime;O'Connor, Michael B.
在昆虫中，身体大小的控制与营养质量以及调节发育过渡时间的环境和遗传线索密切相关。促胸激素（pth）被认为在调节蜕皮激素的产生和/或释放中起重要作用，蜕皮激素是一种刺激蜕皮和变态的类固醇激素。在本报告中，我们研究了切除产生甲状旁腺激素的神经元对果蝇发育的影响。令人惊讶的是，PTTH的产生并不是蜕皮或变态所必需的。相反，失去甲状旁腺激素会导致幼虫发育延迟，并使细胞更多的大蝇羽化。长时间的喂养，没有改变生长速度，导致过度生长，是低激素滴度的结果。这些结果表明，昆虫的最终体型是由胰岛素等生长速率调节剂和PTTH等发育时间线索之间的平衡决定的，后者设定了摄食间隔的持续时间。
In insects, control of body size is intimately linked to nutritional quality as well as environmental and genetic cues that regulate the timing of developmental transitions. Prothoracicotropic hormone (PTTH) has been proposed to play an essential role in regulating the production and/or release of ecdysone, a steroid hormone that stimulates molting and metamorphosis. In this report, we examine the consequences on Drosophila development of ablating the PTTH-producing neurons. Surprisingly, PTTH production is not essential for molting or metamorphosis. Instead, loss of PTTH results in delayed larval development and eclosion of larger flies with more cells. Prolonged feeding, without changing the rate of growth, causes the overgrowth and is a consequence of low ecdysteroid titers. These results indicate that final body size in insects is determined by a balance between growth-rate regulators such as insulin and developmental timing cues such as PTTH that set the duration of the feeding interval.