Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behaviour of epithelial cells.
Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behaviour of epithelial cells.
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发表时间：
1993
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通讯作者：
E. Gherardi;M. Sharpe;K. Lane;A. Sirulnik;M. Stoker
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作者：
E. Gherardi;M. Sharpe;K. Lane;A. Sirulnik;M. Stoker
肝细胞生长因子/分散因子（HGF/SF）是由成纤维细胞和其他间充质细胞产生的多功能蛋白质，对上皮细胞和内皮细胞有活性。该因子共享纤溶酶原和其他血液蛋白酶的基本结构域组织，并作为单链高分子量前体产生，随后被裂解产生生物活性异二聚体。 HGF/SF 通过与细胞表面高亲和力受体结合而作用于靶细胞，该受体具有由 c-met 原癌基因编码的酪氨酸激酶活性。 met 受体对上皮细胞中 HGF/SF 信号的转导导致：(i) 细胞解离，粘附和连接通讯丧失，(ii) 细胞分裂或 (iii) 分化和形态发生。这些反应取决于靶细胞和培养条件。初步证据表明 HGF/SF 在体内发挥作用，表明该因子可能参与胚胎发育的早期阶段和肝再生。已经提出了其在癌症生长或传播中的作用，但仍有待澄清。
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional protein produced by fibroblasts and other mesenchymal cells and active on epithelial and endothelial cells. The factor shares the basic domain organization of plasminogen and other blood proteases and is produced as a single-chain high molecular weight precursor which is subsequently cleaved to produce a biologically active heterodimer. HGF/SF acts on target cells through binding to a cell surface, high-affinity receptor with tyrosine kinase activity encoded by the c-met proto-oncogene. Transduction of the HGF/SF signal in epithelial cells by the met receptor leads either to: (i) cell dissociation, with loss of adhesion and junctional communication, (ii) cell division or (iii) differentiation and morphogenesis. These responses depend on target cells and culture conditions. There is preliminary evidence for a role for HGF/SF in vivo, suggesting that the factor may be involved in the early stages of embryo development and in liver regeneration. A role in cancer growth or dissemination has been proposed but remains to be clarified.