Cortical γ-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder -: A proton magnetic resonance spectroscopy study
Cortical γ-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder -: A proton magnetic resonance spectroscopy study
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DOI：
10.1001/archpsyc.59.9.851
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发表时间：
2002-09-01
影响因子：
--
通讯作者：
Krystal, JH
中科院分区：
文献类型：
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作者：
Epperson, CN;Haga, K;Krystal, JH
背景资料：越来越多的人支持性腺类固醇参与调节人类月经周期调节γ-氨基丁酸（GABA）神经元功能的假设。本研究检验了以下假设：健康女性和经前焦虑障碍（PMDD）患者的大脑皮质GABA神经元功能（反映在大脑GABA浓度上）在整个月经周期内波动，而被诊断为PMDD的女性大脑GABA浓度的月经周期阶段依赖性异常反映了对循环性腺和神经活性类固醇的中枢反应改变。方法：14名健康女性和9名经前抑郁症患者是从一所大学医学中心的女性行为健康研究项目中招募的。这些妇女在月经周期中接受了枕叶皮层GABA水平的连续质子磁共振光谱测量（主要结局指标），并在每个扫描日抽血测定性腺激素和神经类固醇水平（次要结果测量）。有一个显着的组x阶段的相互作用与大多数的发现解释的减少皮质GABA水平在卵泡期在那些与PMDD与健康对照组比较。皮质GABA水平下降，在整个月经周期的健康女性，而女性PMDD经历了增加皮质GABA水平从卵泡期到中期黄体期和晚期黄体期。显着的组间差异，激素和GABA之间的关系，观察雌二醇，孕酮，和allopregnanolone.Conclusions：这些数据强烈表明，GABA能系统的月经周期阶段的健康女性和PMDD的大幅调制。此外，他们提出的可能性，在皮质GABA神经元功能和调制的神经活性类固醇作为潜在的重要贡献者PMDD的发病机制。
Background: There is increasing support for the hypothesis that gonadal steroids involved in the regulation of the human menstrual cycle modulate gamma-aminobutyric acid (GABA) neuronal function. This study tests the hypothesis that cortical GABA neuronal function, reflected in brain GABA concentrations, fluctuates across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder (PMDD) and that a menstrual cycle phase-dependent abnormality in brain GABA concentrations in women diagnosed as having PMDD would reflect altered central response to circulating gonadal and neuroactive steroids.Methods: Fourteen healthy menstruating women and 9 women diagnosed as having PMDD were recruited from a women's behavioral health research program located at a university-based medical center. The women underwent serial proton magnetic resonance spectroscopic measurements of occipital cortex GABA levels across the menstrual cycle (primary outcome measure) and had blood drawn for gonadal hormone and neurosteroid levels determined on each scan day (secondary outcome measure).Results: There was a significant group x phase interaction with most of the finding explained by the reduction in cortical GABA levels during the follicular phase in those with PMDD compared with healthy controls. Cortical GABA levels declined across the menstrual cycle in healthy women, whereas women with PMDD experienced an increase in cortical GABA levels from the follicular phase to the mid luteal and late luteal phases. Significant between-group differences in the relationship between hormones and GABA were observed for estradiol, progesterone, and allopregnanolone.Conclusions: These data strongly suggest that the GABAergic system is substantially modulated by menstrual cycle phase in healthy women and those with PMDD. Furthermore, they raise the possibility of disturbances in cortical GABA neuronal function and modulation by neuroactive steroids as potentially important contributors to the pathogenesis of PMDD.