Adaptation and aftereffects of split-belt walking in cerebellar lesion patients
Adaptation and aftereffects of split-belt walking in cerebellar lesion patients
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DOI：
10.1152/jn.00936.2014
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发表时间：
2015-09-01
影响因子：
2.5
通讯作者：
Duysens, Jacques
中科院分区：
文献类型：
--
作者：
Hoogkamer, Wouter;Bruijn, Sjoerd M.;Duysens, Jacques
为了在各种约束条件下在不同的表面上高效稳定地行走，人类需要在很大程度上调整自己的步态模式。尽管运动适应背后的机制仍不完全清楚，但小脑被认为起着重要作用。在这项研究中，我们的目的是通过比较小脑肿瘤切除后稳定性局灶性病变患者和健康对照组的表现，来解决小脑参与分裂带适应的特定部位。我们观察到，那些与肢体间协调关系最密切的参数(如步长和相对双站时间)的对称性变化在健康对照组和小脑患者中是相似的，在劈带行走过程中和之后。相比之下，在腰带分裂后的早期阶段，患者组的相对站立时间(步态周期中站立的比例)比对照组更不对称。相对站立时间不对称行走的患者更有可能出现Vermal小叶VI和CRU II的损害。这些结果证实了步态适应缺陷因共济失调的严重程度而不同，以及不同类型小脑损害的患者之间的差异。
To walk efficiently and stably on different surfaces under various constrained conditions, humans need to adapt their gait pattern substantially. Although the mechanisms behind locomotor adaptation are still not fully understood, the cerebellum is thought to play an important role. In this study we aimed to address the specific localization of cerebellar involvement in split-belt adaptation by comparing performance in patients with stable focal lesions after cerebellar tumor resection and in healthy controls. We observed that changes in symmetry of those parameters that were most closely related to interlimb coordination (such as step length and relative double stance time) were similar between healthy controls and cerebellar patients during and after split-belt walking. In contrast, relative stance times (proportions of stance in the gait cycle) were more asymmetric for the patient group than for the control group during the early phase of the post-split-belt condition. Patients who walked with more asymmetric relative stance times were more likely to demonstrate lesions in vermal lobules VI and Crus II. These results confirm that deficits in gait adaptation vary with ataxia severity and between patients with different types of cerebellar damage.