The inner ear produces a natriuretic hormone.
The inner ear produces a natriuretic hormone.
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内耳产生利尿钠激素。
DOI：
10.1152/ajprenal.1996.270.6.f1073
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
N. Holstein
中科院分区：
文献类型：
--
作者：
K. Qvortrup;J. Rostgaard;N. Holstein
细胞质颗粒已被证明存在于内淋巴囊的上皮细胞中，内淋巴囊是位于后颅窝的内耳的骨外部分。静脉输注麻醉大鼠内淋巴囊提取物可引起有效的尿钠排泄和利尿作用，而对血压、肾小球滤过率或锂清除率无影响。仅观察到轻微的钾尿。内淋巴囊附近的硬脑膜组织提取物没有影响。结论：内淋巴囊含有内源性钠重吸收抑制剂，可能是“大脑”钠尿排泄的感觉器官/介质。此外，这种物质，暂时命名为saccin，可能会影响内耳液体的稳态，因此在梅尼埃病的发病机制中发挥重要作用。
Cytoplasmic granules have been demonstrated in epithelial cells from the endolymphatic sac, an extraosseus part of the inner ear located in the posterior cranial fossa. Intravenously infused extracts from endolymphatic sacs in anesthetized rats elicited a potent natriuresis and diuresis without effects on blood pressure, glomerular filtration rate, or lithium clearance. Only a minor kaliuresis was observed. Extracts of dural tissue adjacent to the endolymphatic sacs had no effect. It is concluded that the endolymphatic sac contains as endogenous inhibitor of sodium reabsorption and could be the sensory organ/mediator of "cerebral" natriuresis. Furthermore, this substance, tentatively named saccin, may influence the homeostasis of the inner ear fluids and accordingly play a significant role in the pathogenesis of Mèniére's disease.