Interleukin-1β interleukin-18, and interferon-γ expression in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus -: Markers of white matter damage?
Interleukin-1β interleukin-18, and interferon-γ expression in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus -: Markers of white matter damage?
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DOI：
10.1203/pdr.0b013e31805341f1
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发表时间：
2007-06-01
影响因子：
3.6
通讯作者：
Felderhoff-Mueser, Ursula
中科院分区：
文献类型：
--
作者：
Schmitz, Thomas;Heep, Axel;Felderhoff-Mueser, Ursula
出血后脑积水（PHHC）是早产的主要并发症。本研究的目的是确定患有 PHHC 的早产儿脑脊液 (CSF) 中促炎细胞因子 IL-1β、IL-18 和干扰素 (IFN)-γ 的水平是否发生改变，并可能作为白质损伤 (WMD) 的标志物。该研究纳入了 27 名患有 PHHC 的早产儿；其中 13 人在超声检查中发现囊性大规模杀伤性武器 (cWMD) 的迹象。 CSF 样本 1 在第一次脑室造口术中获得，样本 2 在分流器植入时获得。结果与 20 名年龄匹配、无神经系统疾病的患者组成的对照组进行了比较。在无 WMD 的 PHHC 患者的 CSF 样本 1 和患有 cWMD 的患者的样本 1 中，IL-1 β 浓度升高。在未患有 WMD 的患者样本和患有 cWMD 的患者样本 2 中，IL-18 的浓度均有所增加。患有 cWMD 的 PHHC 患者样本 1 的 CSF IFN-γ 水平升高。 PHHC 患者脑脊液中促炎细胞因子 IL-1β 和 IL-18 水平升高。在发生 cWMD 的患者亚组中检测到较高的 IFN-γ 水平，表明其参与了 PHHC 背景下 cWMD 的发病机制。
Posthemorrhagic hydrocephalus (PHHC) represents a major complication of preterm birth. The aim of this study was to determine whether cerebrospinal fluid (CSF) levels of the proinflammatory cytokines IL-1 beta, IL-18, and interferon (IFN)-gamma are altered in the CSF of preterm infants with PHHC and may serve as a marker of white matter damage (WMD). Twenty-seven preterm infants with PHHC were included in the study; 13 of them had signs of cystic WMD (cWMD) on ultrasound examinations. CSF sample 1 was obtained at first ventriculostomy, sample 2 at shunt implantation. Results were compared with a control group of 20 age-matched patients without neurologic diseases. IL-1 beta concentrations were elevated in CSF sample 1 of PHHC patients without WMD and in sample 1 of patients with cWMD. Concentrations of IL-18 were increased in both samples of patients without WMD and in sample 2 of patients with cWMD. CSF levels of IFN-gamma were elevated in sample 1 of PHHC patients with cWMD. The pro-inflammatory cytokine IL-1 beta and IL-18 levels in the CSF are elevated in patients with PHHC. Higher IFN-gamma levels are detected in a subgroup of patients developing cWMD, indicating its involvement in the pathogenesis of cWMD in the context of PHHC.