SJOGREN SYNDROME - CENTRAL NERVOUS-SYSTEM MANIFESTATIONS
SJOGREN SYNDROME - CENTRAL NERVOUS-SYSTEM MANIFESTATIONS
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DOI：
10.1212/wnl.31.11.1391
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发表时间：
1981-01-01
期刊：
影响因子：
9.9
通讯作者：
ALEXANDER, EL
中科院分区：
文献类型：
--
作者：
ALEXANDER, GE;PROVOST, TT;ALEXANDER, EL
对患有原发性干燥综合征和非其他原因的中枢神经系统疾病的患者 (8) 进行了研究。 5 名患者观察到局灶性脑缺损。 5 例患者出现无菌性脑膜脑炎，1 例复发。 3例患者的脊髓表现有多种形式：急性横贯性脊髓炎、慢性进行性脊髓病和脊髓蛛网膜下腔出血。在 8 名患者中的 7 名的血清中检测到 Ro(SSA) 细胞质抗原的沉淀抗体。这可能与干燥综合征中的中枢神经系统疾病的发病机制有关，因为血管炎与这种结缔组织疾病中抗 Ro(SSA) 抗体的存在有很强的相关性。
Patients (8) who had primary Sjogren syndrome and CNS disorders that were not attributable to other casues were studied. Focal cerebral deficits were observed in 5 patients. Aseptic meningoencephalitis was seen in 5 patients, recurrent in one. Spinal cord manifestations in 3 patients took several forms: acute transverse myelitis, chronic progressive myelopathy and spinal subarachnoid hemorrhage. Precipitating antibodies to the Ro(SSA) cytoplasmic antigen were detected in the sera of 7 of 8 patients. This may be relevant to the pathogenesis of CNS disease in Sjogren syndrome, because there is a strong correlation between vasculitis and the presence of anti-Ro(SSA) antibodies in this connective tissue disorder.