Association between caffeine intake and age at onset in Huntington's disease
Association between caffeine intake and age at onset in Huntington's disease
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DOI：
10.1016/j.nbd.2013.05.013
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发表时间：
2013-10-01
影响因子：
6.1
通讯作者：
Krystkowiak, Pierre
中科院分区：
文献类型：
--
作者：
Simonin, Clemence;Duru, Cecile;Krystkowiak, Pierre
咖啡因是一种非选择性腺苷受体（AR）拮抗剂，习惯性摄入咖啡因已被认为对帕金森病和阿尔茨海默病有益。实验证据支持AR在亨廷顿病（HD）中发挥作用，提出了咖啡因可能是HD生活方式调节剂的假设。为了确定咖啡因摄入量与HD发病年龄（AAO）之间的可能关系，我们回顾性评估了80例HD患者的咖啡因摄入量，并使用饮食调查确定与AAO的关系。在调整性别、吸烟状况和CAG重复长度后，咖啡因摄入量大于190 mg/天与AAO早期显著相关。这些数据支持习惯性咖啡因摄入与HD患者AAO之间的关联，但需要进一步研究以了解这些变量之间的联系。(C)2013 Elsevier Inc. All rights reserved.
Habitual consumption of caffeine, a non-selective adenosine receptor (AR) antagonist, has been suggested to be beneficial in Parkinson's and Alzheimer's diseases. Experimental evidence support that ARs play a role in Huntington's disease (HD) raising the hypothesis that caffeine may be a life-style modifier in HD. To determine a possible relationship between caffeine consumption and age at onset (AAO) in HD, we retrospectively assessed caffeine consumption in 80 HD patients using a dietary survey and determined relationship with AAO. Following adjustment for gender, smoking status and CAG repeat length, caffeine consumption greater than 190 mg/day was significantly associated with an earlier AAO. These data support an association between habitual caffeine intake and AAO in HD patients, but further studies are warranted to understand the link between these variables. (C) 2013 Elsevier Inc. All rights reserved.