Diffusion tensor magnetic resonance imaging of the normal breast
Diffusion tensor magnetic resonance imaging of the normal breast
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DOI：
10.1016/j.mri.2009.10.003
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发表时间：
2010-04-01
影响因子：
2.5
通讯作者：
Lehman, Constance D.
中科院分区：
文献类型：
--
作者：
Partridge, Savannah C.;Murthy, Revathi S.;Lehman, Constance D.
目的：探讨乳腺组织弥散张量成像（diffusion tensor imaging， DTI）参数在正常乳腺组织中的范围和可重复性。材料和方法：本研究经我们的机构审查委员会批准，纳入12名健康女性（中位年龄36岁）。在1.5 T时使用弥散加权回波平面成像序列进行弥散张量成像。扩散张量成像参数包括张量特征值(lambda(1)、lambda（2)、lambda(3)）、分数各向异性（FA）和表观扩散系数（ADC）。结果：正常乳腺DTI平均值为lambda(1) =2.51 × 10(-3) mm(2)/s, lambda(2) =1.89 × 10(-3) mm(2)/s, lambda(3) = 1.39 × 10(-3) mm(2)/s， ADC=1.95 +/- 0.24 × 10(-3) mm(2)/s， FA=0.29 +/- 0.05, b=600 s/mm(2)。FA和ADC均存在显著的区域差异(P
Purpose: The objective of this study was to evaluate diffusion anisotropy of the breast parenchyma and assess the range and repeatability of diffusion tensor imaging (DTI) parameters in normal breast tissue.Materials and Methods: The study was approved by our institutional review board and included 12 healthy females (median age, 36 years). Diffusion tensor imaging was performed at 1.5 T using a diffusion-weighted echo planar imaging sequence. Diffusion tensor imaging parameters including tensor eigenvalues (lambda(1), lambda(2), lambda(3)), fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured for anterior, central and posterior breast regions.Results: Mean normal breast DTI measures were lambda(1) =2.51 x 10(-3) mm(2)/s, lambda(2) =1.89 x 10(-3) mm(2)/s, lambda(3) = 1.39 x 10(-3) mm(2)/s, ADC=1.95 +/- 0.24x10(-3) mm(2)/s and FA=0.29 +/- 0.05 for b=600 s/mm(2). Significant regional differences were observed for both FA and ADC (P