WHITE BLOOD-CELL APLASIA ASSOCIATED WITH THYMOMA
WHITE BLOOD-CELL APLASIA ASSOCIATED WITH THYMOMA
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DOI：
10.1093/ajcp/89.2.260
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发表时间：
1988-02-01
影响因子：
3.5
通讯作者：
BARON, JM
中科院分区：
文献类型：
--
作者：
ACKLAND, SP;BUR, ME;BARON, JM
少数获得性发育不良中性粒细胞减少症或纯白细胞再生障碍性贫血(PWCA)与胸腺瘤相关，这与已有文献记载的纯红细胞再生障碍性贫血与胸腺瘤的相关性形成鲜明对比。这些疾病中再生障碍性疾病的机制尚不清楚。作者报告1例骨髓中完全缺乏造血细胞的间变性梭形细胞胸腺瘤患者的PWCA，患者血清可抑制自体粒细胞-巨噬细胞集落形成单位。这一发现提示了该患者PWCA发病的体液自身免疫机制，并支持了与胸腺瘤相关的所有血液现象可能都有自身免疫基础的可能性。
A limited number of cases of acquired hypoplastic neutropenia or pure white blood cell aplasia (PWCA) associated with thymoma have been reported, in contrast to the well-documented association of pure red blood cell aplasia and thymoma. The mechanism of the aplasia in these disorders is unclear. The authors report a case of PWCA (with total absence of all granulopoietic elements in the bone marrow) in a patient with meta-static spindle cell thymoma, in which suppression of autologous granulocyte-macrophage colony-forming units by the patient’s serum could be demonstrated. This finding suggests a humoral autoimmune mechanism for the pathogenesis of PWCA in this patient and lends support to the possibility that all hematologic phenomena associated with thymoma may have an autoimmune basis.