Role of right and left atria in natriuresis and atrial natriuretic factor release during blood volume changes in the conscious rat.
Role of right and left atria in natriuresis and atrial natriuretic factor release during blood volume changes in the conscious rat.
复制标题
清醒大鼠血容量变化过程中左右心房在尿钠排泄和心房钠尿因子释放中的作用。
DOI：
10.1161/01.res.61.1.99
复制
发表时间：
1987
影响因子：
20.1
通讯作者：
G. Thibault
中科院分区：
文献类型：
--
作者：
R. Garcia;M. Cantin;G. Thibault
本研究探讨是否切除右或左心耳的大鼠改变他们的利钠反应和释放心房利钠因子在急性血容量扩张或减少。对这些动物进行胸廓切开术，并切除其右或左心房阑尾或进行右或左心房假阑尾切除术，以进行比较和对照。3-4周后，在戊巴比妥钠麻醉下安装颈静脉、颈动脉和膀胱内导管。然后，当大鼠清醒时，以5 ml/kg/min的速率，每15分钟使用供体大鼠的血液以计算的总血量的10%的3个增量进行一次血容量扩增。在容量扩增前和每15分钟结束时收集血液和尿液样品，并更换抽取的血液。除右心房阑尾切除动物外，所有动物的尿量、尿钠排泄量和血浆心钠素最大增加4倍。血浆心钠素、尿量和尿钠排泄量在所有4组中均相关。未观察到血压或红细胞压积的显著变化。血浆血管加压素，在扩容结束时测量，在左心房阑尾切除术的动物显着较低。来自对照组的血浆的高效液相色谱法表明，在血容量扩张期间释放的ANF的大部分对应于高分子量肽。对如上处理的其他大鼠进行10%血容量减量。（250字处删节）
This study investigated whether excision of either the right or left atrial appendage of rats alters their natriuretic response and the release of atrial natriuretic factor during acute blood volume expansion or reduction. These animals were subjected to a thoracotomy and either had their right or left atrial appendages removed or underwent a right or left atrial sham appendectomy for comparative, control purposes. Intrajugular vein, intracarotid artery, and intravesical catheters were installed 3-4 weeks later under sodium pentobarbital anesthesia. Then, when the rats were conscious, blood volume was expanded using blood from donor rats once every 15 minutes in 3 increments of 10% of the calculated total blood volume at a rate of 5 ml/kg/min. Blood and urine samples were collected before volume expansion and at the end of each 15-minute period, with the withdrawn blood being replaced. A maximal fourfold increase in urinary volume, urinary sodium excretion, and plasma atrial natriuretic factor was observed in all but the right-atrial-appendectomized animals. Plasma atrial natriuretic factor, urinary volume, and urinary sodium excretion were correlated in all 4 groups. No significant changes in blood pressure or hematocrit were noted. Plasma vasopressin, measured at the end of volume expansion, was significantly lower in animals subjected to left atrial appendectomy. High-performance liquid chromatography of plasma from the control groups indicated that most of the released ANF during blood volume expansion corresponded to a high molecular weight peptide. Additional rats, processed as above, were subjected to 10% blood volume decrements.(ABSTRACT TRUNCATED AT 250 WORDS)
心房钠尿因子抑制脱水和出血引起的加压素释放。
影响因子：
4.1
作者：
Samson,WK
通讯作者：
Samson,WK