Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia
Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia
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DOI：
10.1016/j.schres.2005.05.010
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发表时间：
2005-10-01
影响因子：
4.5
通讯作者：
DeLisi, LE
中科院分区：
文献类型：
--
作者：
Hoff, AL;Svetina, C;DeLisi, LE
我们先前报道了精神分裂症首次发作后4- 5年内神经心理功能的相对稳定性，患者在某些功能上的改善程度低于对照组[霍夫，A.L.，Sakuma，M.，Wieneke，M.，霍龙河Kushner，M.，DeLisi，L.E.，1999.精神分裂症首发后神经心理功能的纵向随访研究美国精神病学杂志156，1336-1341。目前的研究是通过10年的疾病来延长随访评估，以确定神经心理功能是否在较长时间内保持稳定或恶化。21例首发患者和8例对照者在神经心理学和临床指标初步评估后10年进行了重新评估。重复测量分析表明，在这段时间内，患者和对照组之间的变化程度没有差异，症状的变化也与认知能力的改善或恶化无关。然而，认知功能的基线水平与变化程度相关。因此，当在分析中控制基线功能水平时，与对照组相比，患者在言语智力功能、延迟言语和非言语回忆以及认知抑制（Stroop色词测试）方面的改善较少或缺乏。在任何测试中，患者的病情恶化程度都没有明显超过对照组。我们的结论是，大多数首次发病的患者在首次住院时已经有相当大的认知能力下降，并且在至少10年的疾病中保持相对稳定。大多数认知变化发生在这种疾病的早期，在第一次住院之前，但其确切的时间仍然未知。(c)2005 Elsevier BV保留所有权利。
We previously reported relative stability in neuropsychological functions over a 4- to 5-year period after the onset of a first episode of schizophrenia, with patients demonstrating less improvement than controls on some functions [Hoff, A.L., Sakuma, M., Wieneke, M., Horon, R., Kushner, M., DeLisi, L.E., 1999. A longitudinal follow-up study of neuropsychological functioning subsequent to a first-episode of schizophrenia. American Journal of Psychiatry 156, 1336-1341.]. The current study was conducted to extend follow-up evaluations through 10 years of illness to determine whether neuropsychological functions remain stable or deteriorate over a longer time period. Twenty-one first episode patients and 8 controls were re-evaluated 10 years after an initial evaluation on neuropsychological and clinical measures. Repeated measures analyses demonstrated no differences between patients and controls in degree of change over this time period nor was change in symptoms reliably associated with improvement or deterioration in cognitive abilities. However, baseline level of cognitive functioning was correlated with the degree of change. Thus, when the baseline level of functioning was controlled for in the analyses, less or lack of improvement was seen in the patients compared with controls in verbal intellectual functioning, delayed verbal and nonverbal recall, and cognitive inhibition (Stroop Color Word Test). In no test did patients deteriorate significantly more than controls. We conclude that most first episode patients have had considerable cognitive decline by the time of their first hospitalization and that it remains relatively stable through at least 10 years of illness. Most cognitive change takes place early in this illness, prior to the first hospitalization, but its exact timing still remains unknown. (c) 2005 Elsevier BV All rights reserved.