Vilsmeier-Haack reactions of 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans toward the synthesis of highly substituted pyridin-2(1H)-ones.
Vilsmeier-Haack reactions of 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans toward the synthesis of highly substituted pyridin-2(1H)-ones.
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DOI：
10.1021/jo7015482
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发表时间：
2007-10
期刊：
影响因子：
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通讯作者：
Dexuan Xiang;Yang Yang-Yang;Rui Zhang;Yongjiu Liang;W. Pan;Jie Huang;D. Dong
中科院分区：
文献类型：
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作者：
Dexuan Xiang;Yang Yang-Yang;Rui Zhang;Yongjiu Liang;W. Pan;Jie Huang;D. Dong
A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones was developed via Vilsmeier-Haack reactions of readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed.
