Generic Molding Platform for Simple, Low-Cost Fabrication of Polymeric Microneedles
Generic Molding Platform for Simple, Low-Cost Fabrication of Polymeric Microneedles
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DOI：
10.1002/mame.202000072
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发表时间：
2020-04-27
影响因子：
3.9
通讯作者：
Subrahmanyam, Dinesh N.
中科院分区：
文献类型：
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作者：
Badnikar, Kedar;Jayadevi, Shreyas N.;Subrahmanyam, Dinesh N.
微成型技术广泛用于制造用于透皮和皮内药物输送应用的聚合物微针。成型中微针的几何特征完全由主模具模板的几何形状决定。由于微针典型的特征尺寸较小，主模具模板的制造通常涉及昂贵且繁琐的技术。在这项研究中，设计了一种新颖的成型平台，该平台采用低成本、简单的技术制造，能够灵活地生产大量微针几何形状。所提出的成型平台无需开发多个模具模板来制造各种几何形状的聚合物微针。该成型平台的实用性在具有各种长宽比设置的聚乳酸基固体热塑性微针和聚丙烯酸基可溶性微针中得到了证明。使用成型平台中的指定设置，可以成功实现以不同高度制造的各种微针，分辨率低至 100 μm。通过体外和体内测试评估制造的微针对于药物输送应用的适用性。
Micromolding technology is widely used for the fabrication of polymer microneedles for transdermal and intradermal drug delivery applications. Geometric features of microneedles in molding are solely determined by geometry of the master mold template. Fabrication of master mold template usually involves costly and cumbersome technologies due to small feature sizes typical of microneedles. In this research, a novel molding platform is designed that is fabricated using low-cost and simple techniques with flexibility of producing large number of microneedle geometries. The proposed molding platform eliminates need for developing multiple mold templates for fabrication of various geometries of polymer microneedles. Utility of this molding platform is demonstrated in polylactic acid-based solid thermoplastic microneedles and polyacrylic acid-based dissolvable microneedles with various aspect ratio settings. Various microneedles fabricated at heights differing with resolution of as low as 100 mu m are successfully achieved using specified settings in the molding platform. The suitability of fabricated microneedles for drug delivery applications is evaluated by in vitro and in vivo testing.