SEQUENCE OF AN UNUSUALLY LARGE PROTEIN IMPLICATED IN REGULATION OF MYOSIN ACTIVITY IN C-ELEGANS
SEQUENCE OF AN UNUSUALLY LARGE PROTEIN IMPLICATED IN REGULATION OF MYOSIN ACTIVITY IN C-ELEGANS
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DOI：
10.1038/342045a0
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发表时间：
1989-11-02
期刊：
影响因子：
64.8
通讯作者：
WATERSTON, RH
中科院分区：
文献类型：
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作者：
BENIAN, GM;KIFF, JE;WATERSTON, RH
秀丽隐杆线虫基因c-22编码一种非常大的肌肉蛋白，称为抽搐蛋白，它由一个蛋白激酶结构域和两个短基元的几个拷贝组成。twitchin的序列与免疫球蛋白超家族、细胞粘附分子和脊椎动物肌肉蛋白（包括肌球蛋白轻链激酶）的序列有着意想不到的相似性。这些同源性，连同早期遗传和分子分析的结果，表明twitchin参与了一种新的肌球蛋白调节机制。
TheCaenorhabditis elegansgeneunc-22encodes a very large muscle protein, called twitchin, which consists of a protein kinase domain and several copies of two short motifs. The sequence of twit-chin has unexpected similarities to the sequences of proteins of the immunoglobulin superfamily, cell adhesion molecules and vertebrate muscle proteins, including myosin light-chain kinase. These homologies, together with results from earlier genetic and molecular analyses, indicate that twit-chin is involved in a novel mechanism of myosin regulation.