Association of metabolic syndrome with inflammatory mediators in women with previous gestational diabetes mellitus.
Association of metabolic syndrome with inflammatory mediators in women with previous gestational diabetes mellitus.
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DOI：
10.1186/2251-6581-12-8
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发表时间：
2013-01-22
影响因子：
2.8
通讯作者：
Fakhrzadeh H
中科院分区：
文献类型：
--
作者：
Edalat B;Sharifi F;Badamchizadeh Z;Hossein-Nezhad A;Larijani B;Mirarefin M;Fakhrzadeh H
在既往患有妊娠期糖尿病 (pGDM) 的女性中，观察到代谢综合征 (MS) 的风险增加。通常伴随着 C 反应蛋白 (CRP) 和白细胞介素 6 (IL-6) 等炎症标志物的增加。我们进行这项调查是为了检查 pGDM 与 MS、CRP 和 IL-6 之间的关系。 77 名患有 pGDM 的女性和 67 名随机抽取的未患有 GDM 的女性在指数妊娠后 2-3 年参与了这项研究。进行了实验室和人体测量。 MS 根据 ATP III 标准定义。使用 SPSS 18 进行统计分析。患有和不患有 pGDM 的组之间的 CRP 存在差异 [分别为 2.69 (2.86 mg/dl 和 1.56 (1.39) mg/dl；p < 0.01]。除空腹血糖外，每种 MS 成分本身的存在与显着较高的 CRP 水平相关。在线性回归模型中，CRP 和 IL-6 与 BMI 显着相关（β = 0.01）。 25, 0.23; p < 0.01)、腰围 (β=0. 27, 0.05; p < 0.01) 和 HOMA-IR (β=0. 39, 0.39; p < 0.01)。调整年龄和 BMI 后，高 CRP 和 MS 组中 pGDM 的发生与 CRP 水平显着相关 (OR= 5.11; p < 0.01)。 CI=1.59-16.43；p < 0.01），由于患有 pGDM 和 MS 的女性中 CRP 和 IL-6 较高，因此 pGDM 与 MS 成分的存在对炎症标志物的血清水平升高具有协同作用，这可能部分是由于内脏肥胖所致。
An increased risk of metabolic syndrome (MS) has been observed among women with previous gestational diabetes mellitus (pGDM). Increased inflammatory markers such as C-reactive protein (CRP) and interleukin 6 (IL-6) usually accompany. We performed this survey to examine the relationship between pGDM and MS, CRP and IL-6. 77 women with pGDM and 67 randomly sampled women free from GDM participated in this study, 2–3 years after index pregnancy. Laboratory and anthropometric measurements were performed. MS was defined according to ATP III criteria. Statistical analyses were conducted using SPSS 18. CRP were different between groups with and without pGDM [2.69 (2.86 mg/dl and 1.56 (1.39) mg/dl, respectively; p < 0.01]. The presence of each MS component by itself was associated with significantly higher CRP Levels, except for fasting blood glucose. In linear regression models, CRP and IL-6 were significantly associated with BMI (β =0. 25, 0.23; p < 0.01), waist circumference (β=0. 27, 0.05; p < 0.01) and HOMA-IR (β=0. 39, 0.39; p < 0.01). After adjustment for age and BMI the occurrence of pGDM in the group with both high CRP and MS was significantly associated with CRP level (OR= 5.11; CI=1.59-16.43; p < 0.01). Since CRP and Il-6 were higher in women with both pGDM and MS it appears that the presence of pGDM with MS components have a synergistic effect on the elevation of serum levels of inflammatory markers which can be partly as a result of visceral obesity. Further long-term studies are necessary to confirm the relationship between CRP, IL-6 and MS in women with pGDM.