Mitosis of the rat anterior pituitary cells: an electron microscope study.
Mitosis of the rat anterior pituitary cells: an electron microscope study.
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大鼠垂体前叶细胞的有丝分裂：电子显微镜研究。
DOI：
10.1679/aohc1950.33.145
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
K. Kurosumi
中科院分区：
文献类型：
--
作者：
K. Kurosumi
用电镜观察了大鼠垂体前叶细胞的有丝分裂。在垂体前叶发现的大多数有丝分裂细胞含有许多分泌颗粒，中期的生长营养细胞含有高尔基体和新形成的分泌颗粒。甲状腺切除术后肥大的甲状腺细胞发生有丝分裂。在有丝分裂过程中，一些泌乳素产生细胞含有大量粗内质网空泡池，这是雌性大鼠长期服用雌激素的特征性结果。切除靶器官或使用雌激素后，垂体前叶肥大可能是由与实验相对应的特定类型细胞的增殖引起的。这种增殖是由完全分化的腺垂体细胞的有丝分裂细胞进行的。高度分化的细胞产生特定激素不能合成DNA并通过有丝分裂进行分裂的理论被证明是错误的。着丝点外层在染色体纺锤体小管的拉力作用下发生弯曲。由于内层在这种情况下没有弯曲，很明显纺锤体小管没有穿透着丝点，染色体小管的收缩被认为对后期染色体的初始运动施加了力。
Mitosis of the rat anterior pituitary cells was studied with the electron microscope. Most mitotic cells found in the anterior pituitary contained a number of secretory granules, and a somatotrophic cell in metaphase contained a Golgi apparatus with newly formed secretory granules. Hypertrophied thyrotrophic cells after thyroidectomy underwent mitosis. Some prolactin-producing cells in mitosis contained a great number of vacuolated cisterns of rough endoplasmic reticulum, which were the characteristic results of long term administration of estrogen to female rats. Hypertrophy of the anterior pituitary glands after removal of a target organ or the administration of estrogen may be brought about by the proliferation of cells of a specific type corresponding to the experiment. This proliferation carried out by mitotic cell division of fully differentiated adenohypophyseal cells. The theory that highly differentiated cells producing specific hormone cannot synthesize DNA and divide by mitosis was shown to be erroneous.The outer layer of a kinetochore was bent by the pulling force of chromosomal spindle tubules. As the inner layer was not bent in this case, it became clear that the spindle tubules do not penetrate through the kinetochore, and the contraction of chromosomal tubules is believed to exert the force for the initial movement of anaphase chromosomes.