Gender differences in knee joint cartilage thickness, volume and articular surface areas:: assessment with quantitative three-dimensional MR imaging
Gender differences in knee joint cartilage thickness, volume and articular surface areas:: assessment with quantitative three-dimensional MR imaging
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DOI：
10.1007/s002560000320
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发表时间：
2001-03-01
影响因子：
2.1
通讯作者：
Reiser, M
中科院分区：
文献类型：
--
作者：
Faber, SC;Eckstein, F;Reiser, M
目的：比较年轻健康的非运动女性和男性的膝关节软骨厚度、体积和关节表面积。主题和设计。对18名无局部或全身性关节疾病的健康受试者（9名女性，年龄22.3 +/-2.4岁，9名男性，年龄22.2 +/-1.9岁）进行磁共振成像，采用脂肪抑制的FLASH 3D脉冲序列（TR=41 ms， TE=11 ms， FA=30度），矢状定向，空间分辨率为2x0.31x0.31 mm(3)。对膝关节软骨板进行三维重建和三角剖分后，量化软骨厚度（平均和最大）、体积和关节表面积大小，而不依赖于原始切片方向。结果和结论：女性的软骨体积比男性小，百分比差异从髌骨的19.9%到胫骨内侧的46.6%不等。软骨厚度的性别差异较小，股骨滑车的平均厚度从2.0%到胫骨内侧的13.3%不等，股骨内侧髁的软骨厚度从4.3%到胫骨内侧的18.3%不等。软骨表面积之间的差异与体积之间的差异相似，其值从股骨的21.0%到胫骨外侧的33.4%不等。将软骨体积和表面积与体重和体重×身高归一化后，性别差异可以减小。该研究表明，男性和女性在软骨体积和表面积上存在显著的性别差异，在回顾性评估有退行性关节疾病症状患者的关节软骨损失时，需要考虑到这一点。软骨体积的差异主要是由于关节表面积（骨骺大小）的差异，而不是软骨厚度的差异。
Objective: To compare the cartilage thickness, volume, and articular surface areas of the knee joint between young healthy, non-athletic female and male individuals. Subjects and design. MR imaging was performed in 18 healthy subjects without local or systemic joint disease (9 female, age 22.3 +/-2.4 years, and 9 male, age 22.2 +/-1.9 years.), using a fat-suppressed FLASH 3D pulse sequence (TR=41 ms, TE=11 ms, FA=30 degrees) with sagittal orientation and a spatial resolution of 2x0.31x0.31 mm(3). After three-dimensional reconstruction and triangulation of the knee joint cartilage plates, the cartilage thickness (mean and maximal), volume, and size of the articular surface area were quantified, independent of the original section orientation.Results and conclusions: Women displayed smaller cartilage volumes than men, the percentage difference ranging from 19.9% in the patella, to 46.6% in the medial tibia. The gender differences of the cartilage thickness were smaller, ranging from 2.0% in the femoral trochlea to 13.3% in the medial tibia for the mean thickness, and from 4.3% in the medial femoral condyle to 18.3% in the medial tibia for the maximal cartilage thickness. The differences between the cartilage surface areas were similar to those of the volumes, with values ranging from 21.0% in the femur to 33.4% in the lateral tibia. Gender differences could be reduced for cartilage volume and surface area when normalized to body weight and body weightxbody height. The study demonstrates significant gender differences in cartilage volume and surface area of men and women, which need to be taken into account when retrospectively estimating articular cartilage loss in patients with symptoms of degenerative joint disease. Differences in cartilage volume are primarily due to differences in joint surface areas (epiphyseal bone size), not to differences in cartilage thickness.