Spontaneous blood pressure oscillations and cerebral autoregulation
Spontaneous blood pressure oscillations and cerebral autoregulation
复制标题
DOI：
10.1007/bf02267598
复制
发表时间：
1998-02-01
影响因子：
5.8
通讯作者：
Berlit, P
中科院分区：
文献类型：
--
作者：
Diehl, RR;Linden, D;Berlit, P
分析正常人脑血流速度（CBFV）自发振荡与动脉血压（ABP）的关系，以评价这些关系是否提供有关脑自动调节的信息。在50名志愿者中，使用经颅多普勒超声和Finapres连续ABP和心率测量CBFV。测量在仰卧位进行5分钟，在倾斜位进行6分钟。使用功率和交叉频谱分析计算变异系数，以量化两个频率范围内的振幅：3-9个周期/分钟（cpm）（M波）和9-20 cpm（R波）。还计算了CBFV和ABP中相应波之间的相关性、相干值、相角偏移和增益。CBFV和ABP之间的M波和R波存在明显的相关性，相干值足够大，可以计算相位角偏移和增益。M波的相位角较大，增益低于R波的情况下，无论是倾斜或仰卧。这些数据与大脑自动调节的高通滤波器模型一致。相对较高的CBFV/ABP增益值（在1.4和2.0之间）表明，除了自动调节反馈机制之外，还必须考虑频率依赖性血管输入阻抗的原理。M波和R波范围内的自发ABP振荡可作为连续自动调节监测的基础。(C)1998 Rapid Science Ltd.
The relationship between spontaneous oscillations in cerebral blood flow velocity (CBFV) and arterial blood pressure (ABP) was analysed in normal subjects in order to evaluate whether these relationships provide information about cerebral autoregulation. CBFV was measured using transcranial Doppler sonography and continuous ABP and heart rate using Finapres in 50 volunteers. Measurements were made over 5 min in a supine position and 6 min in a tilted position. Coefficients of variation were calculated using power-and cross-spectral analysis in order to quantify amplitudes within two frequency ranges: 3-9 cycles per min (cpm) (M-waves); and 9-20 cpm (R-waves). Correlations, coherence values, phase angle shifts and gains were also computed between corresponding waves in CBFV and in ABP. A clear correlation was seen for M-waves and R-waves between CBFV and ABP and coherence values were large enough to calculate phase angle shifts and gains. Phase angles for M-waves were larger and gains lower than was the case for R-waves, either tilted or supine. These data are consistent with a highpass filter model of cerebral autoregulation. Relatively high CBFV/ABP gain values (between 1.4 and 2.0) suggest that the principle of frequency-dependent vascular input impedances has to be considered in addition to autoregulatory feedback mechanisms. Spontaneous ABP oscillations in the M-wave and R-wave ranges may serve as a basis for continuous autoregulation monitoring. (C) 1998 Rapid Science Ltd.