MR imaging characterization of postischemic myocardial dysfunction („stunned myocardium”︁): Relationship between functional and perfusion abnormalities
MR imaging characterization of postischemic myocardial dysfunction („stunned myocardium”︁): Relationship between functional and perfusion abnormalities
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缺血后心肌功能障碍（“心肌顿抑”）的 MR 成像特征：功能异常与灌注异常之间的关系
DOI：
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发表时间：
1996
影响因子：
4.4
通讯作者：
C. Higgins
中科院分区：
文献类型：
--
作者：
D. Szolar;M. Saeed;M. Wendland;H. Sakuma;T. Roberts;M. Stiskal;N. Derugin;C. Higgins
在溶栓药物治疗成功的患者中可检测到顿抑心肌。本研究的假设是，快速梯度回波（GRE）成像可用于表征指示心肌顿抑的局部功能和灌注异常。本研究旨在分别通过快速（分段k空间）电影和对比增强GRE成像监测和关联壁厚和灌注异常的程度。对犬进行左回旋支（LCX）冠状动脉闭塞（15 min），然后再灌注30 min（n = 8）。血管周围血流探头用于连续测量左前降支（LAD）和LCX冠状动脉的血流。短轴倒置恢复准备快速GRE和电影图像是在基线、闭塞以及再流1、10和30分钟时采集的。在26个等间距的圆周位置确定区域信号强度和收缩期壁增厚百分比，以比较功能和灌注异常的程度。在闭塞和再灌注期间，缺血区域在对比增强图像上分别显示为低信号和高信号区域。在闭塞期间，灌注缺损的程度（赤道切片周长的32% ± 2%）与收缩功能障碍的程度（35% ± 2%）密切相关（r = 0.74）。再灌注后，壁增厚百分比短暂恢复（26% ± 4% vs 36% ± 4%正常），与反应性充血反应一致，但随后在10分钟（19% ± 4%）和30分钟（12% ± 2%）时壁增厚显著下降。快速MR成像可能有助于监测溶栓治疗后缺血后心肌异常和药物干预的反应。
Stunned myocardium has been detected in patients treated successfully with thrombolytic agents. The hypothesis of this study was that fast gradient echo (GRE) imaging could be used to characterize the regional functional and perfusion abnormalities that are indicative of myocardial stunning. This study was designed to monitor and correlate the extent of wall thickness and perfusion abnormalities as determined by fast (segmented k space) cine and contrast enhanced GRE imaging, respectively. Dogs were subjected to left circumflex (LCX) coronary artery occlusion (15 min) followed by 30‐minute reperfusion (n = 8). Perivascular flow probes were used to continuously measure flow in left anterior descending (LAD) and LCX coronary arteries. Short‐axis inversion recovery prepared fast GRE and cine images were acquired at baseline, at occlusion, and at 1, 10, and 30 minutes of reflow. Regional signal intensity and percent systolic wall thickening were determined at 26 equally spaced circumferential positions to compare the extent of functional and perfusion abnormalities. During occlusion and reperfusion, the ischemic region was demonstrated on contrast‐enhanced images as a hypointense and hyperintense region, respectively. During occlusion, the extent of the perfusion defect (32% ± 2% of the circumference of the equatorial slice) correlated closely (r = .74) with the extent of contractile dysfunction (35% ± 2%). After reperfusion, there was transient recovery in the percent wall thickening (26% ± 4% vs 36% ± 4% normal), coinciding with the reactive hyperemic response, but this was followed by a significant decline in wall thickening at 10 minutes (19% ± 4%) and 30 minutes (12% ± 2%). Fast MR imaging may be useful to monitor postischemic myocardial abnormalities after thrombolytic therapy and the response to pharmacologic interventions.
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区域缺血期间相邻心肌节段的相互功能相互作用：影响完整心脏中明显区域收缩功能的心室内负荷现象。
影响因子：
24
作者：
Smalling,RW;Ekas,RD;Felli,PR;Binion,L;Desmond,J
通讯作者：
Desmond,J
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DOI：
10.1152/ajpheart.1981.240.5.h709
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Dole,WP;Montville,WJ;Bishop,VS
通讯作者：
Bishop,VS
通过对顿顿心肌进行配对起搏，可提高局部心肌效率以及灌注、氧化和功能储备的持续性。
影响因子：
37.8
作者：
Bergmann,SR;Weinheimer,CJ;Brown,MA;Perez,JE
通讯作者：
Perez,JE
急性心肌梗死冠状动脉内输注链激酶后受损心肌的功能改善。
DOI：
10.1172/jci110987
发表时间：
1983
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Stack,RS;Phillips3rd,HR;Grierson,DS;Behar,VS;Kong,Y;Peter,RH;Swain,JL;GreenfieldJr,JC
通讯作者：
GreenfieldJr,JC
用于评估超声心动图壁增厚和运动的中心线方法的修改：与风险区域的比较。
影响因子：
24
作者：
McGillem,MJ;Mancini,GB;DeBoe,SF;Buda,AJ
通讯作者：
Buda,AJ