MIGRATION AND DIFFERENTIATION OF GANGLION-CELLS IN OPTIC TECTUM OF CHICK-EMBRYO
MIGRATION AND DIFFERENTIATION OF GANGLION-CELLS IN OPTIC TECTUM OF CHICK-EMBRYO
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DOI：
10.1016/0306-4522(77)90011-2
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发表时间：
1977-01-01
期刊：
影响因子：
3.3
通讯作者：
MOREST, DK
中科院分区：
文献类型：
--
作者：
DOMESICK, VB;MOREST, DK
顶盖深灰色层的神经节细胞的特征是有大的核周和长而厚的树突，广泛扩散到覆盖的中间层和浅层。它的轴突从体体的腹侧伸入邻近的深白色层，并与传出顶盖纤维切向延伸。在一系列分阶段胚胎[和幼鸡]的快速高尔基体制备物中，追踪了神经节细胞成神经细胞从基质区迁移到其确定位置的过程。神经母细胞显然直到最后一次细胞分裂后 1-2 天才开始迁移。最初，有丝分裂后神经母细胞是细长的细胞，其核周位于基质区，原始外部突起径向延伸穿过外套膜和边缘区。在细胞体迁移之前，轴突从外部突起中长出，从而阻止了整个细胞的运动。这些早期形成的轴突形成了纤维层，这是地幔区的前身。神经母细胞的迁移是通过引导过程的延长和细胞体在该过程中的易位来完成的。在迁移过程中可以观察到 3 个阶段：径向、切向和倾斜。在每个阶段中，前导过程相应的径向、切向或倾斜方向定义了细胞体的迁移路线。对于这些迁移路线，支持细胞或神经胶质细胞没有一致的排列。在神经节细胞层中确定位置后，年轻的神经元形成树突。这种显着的形态学事件序列不能用整个细胞的运动或神经母细胞迁移和分化的细胞指导的当前概念来解释。控制迁移的因素可能与参与神经母细胞生长和伸长的因素同时发生，甚至可能相同。
The ganglion cell of the deep gray layer of the tectum [of Gallus gallus] is characterized by a large perikaryon and long thick dendrites spreading widely into the overlying intermediate and superficial layers. Its axon projects from the ventral aspect of the soma into the adjacent deep white layer and runs tangentially with the efferent tectal fibers. Migration of the ganglion cell neuroblast from the matrix zone to its definitive location was traced in rapid Golgi preparations from a series of staged embryos [and young chicks]. The neuroblast apparently does not begin to migrate until 1-2 days after its last cell division. Initially, the postmitotic neuroblast is an elongated cell, its perikaryon in the matrix zone and primitive external process extending radially through the mantle and marginal zones. Before the cell body migrates, an axon grows out from the external process, thus preventing movement of the cell as a whole. These early-forming axons establish a fiber layer, which is the forerunner of the mantle zone. The migration of the neuroblast is accomplished by elongation of a leading process and translocation of the cell body through the process. A sequence of 3 stages can be observed in the migration: radial, tangential and oblique. In each of these stages, the corresponding radial, tangential or oblique orientation of the leading process defines the migration route of the cell body. There is no consistent arrangement of supporting cells or neuroglia with respect to these migration routes. After its definitive location in the ganglion cell layer, the young neuron forms dendrites. This remarkable sequence of morphological events is not explained by locomotion of the entire cell or by current notions of cellular guidance of the neuroblast in migration and differentiation. The factors controlling migration are probably contemporaneous with, and perhaps the same as, those involved in the growth and elongation of the neuroblast.