Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants
Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants
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DOI：
10.1016/j.neuroimage.2005.05.018
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发表时间：
2005-10-01
期刊：
影响因子：
5.7
通讯作者：
Henry, RG
中科院分区：
文献类型：
--
作者：
Berman, JI;Mukherjee, P;Henry, RG
弥散张量MRI（DTI）纤维追踪是第一个非侵入性和体内技术的划定和定量的具体白色物质的途径。在这项研究中，定量纤维跟踪被用来评估的结构发展的运动束和体感辐射在早产儿人类新生儿。这些通路在最年幼的早产儿中是无髓鞘的，并且在晚期早产成熟期间开始髓鞘化。以前的研究只能描绘出这些通路的部分，这些通路可以基于解剖标志在2D中手动勾画。此外，这些先前的研究不能将运动区和感觉区分开。一个高灵敏度的新生儿头部线圈与MR兼容的恒温箱结合使用，以执行早产儿大脑的高分辨率成像。37例胎龄在28 ~ 43周的早产儿采用3D-DTI纤维追踪技术成功地勾画出了运动和躯体感觉束。两个流线确定性和概率方法进行定量纤维束成像。从运动和感觉通路获得了弥散参数的特定测量值，包括分数各向异性、方向平均弥散度和特征值。使用确定性和probabitistic纤维跟踪，所有特定的道扩散参数被发现是显着相关的年龄和运动道被发现具有较高的各向异性和较低的扩散比感觉通路。通过切片分割3D纤维轨迹，发现大脑不同轴向水平的测量值随区域和年龄而变化。总之，确定性和概率性DTI纤维追踪方法被用来量化早产儿运动和体感通路的发育变化。(C)2005年爱思唯尔公司All rights reserved.
Diffusion tensor MRI (DTI) fiber tracking is the first non-invasive and in vivo technique for the delineation and quantitation of specific white matter pathways. In this study, quantitative fiber tracking was used to assess the structural development of the motor tract and somatosensory radiation in premature human newborns. These pathways are unmyelinated in the youngest premature infants and begin to myelinate during late preterm maturation. Previous studies have only been able to delineate parts of these pathways that could be manually outlined in 2D based on anatomical landmarks. Furthermore, these previous studies could not separate motor and sensory regions. A high-sensitivity neonatal head coil was employed in conjunction with an MR-compatible incubator to perform high-resolution imaging of the premature infant brain. The motor and somatosensory tracts were successfully delineated with 3D DTI fiber tracking in 37 exams of preterm newborns between 28 and 43 weeks gestational age. Both streamline deterministic and probabilistic methods were employed to perform quantitative fiber tractography. Tract-specific measurements of diffusion parameters including fractional anisotropy, directionatly averaged diffusivity, and eigenvalues were obtained from the motor and sensory pathways. Using both deterministic and probabitistic fiber tracking, all tract-specific diffusion parameters were found to be significantly correlated with age and the motor tracts were found to have higher anisotropy and lower diffusivity than the sensory pathway. By segmenting the 3D fiber tracks by slice, measurements from different axial levels of the brain were found to vary with region and age. In summary, deterministic and probabilistic DTI fiber tracking methods were used to quantify the developmental changes of motor and somatosensory pathways in premature infants. (C) 2005 Elsevier Inc. All rights reserved.