Gustatory responses of cortical neurons in rats. II. Information processing of taste quality.
Gustatory responses of cortical neurons in rats. II. Information processing of taste quality.
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DOI：
10.1152/jn.1985.53.6.1356
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发表时间：
1985-06
影响因子：
2.5
通讯作者：
T. Yamamoto;N. Yuyama;T. Kato;Y. Kawamura
中科院分区：
文献类型：
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作者：
T. Yamamoto;N. Yuyama;T. Kato;Y. Kawamura
本研究旨在探讨大鼠大脑皮层味觉区味觉信息的神经编码。大小和/或类型（兴奋，抑制，或无反应）的反应，111皮层神经元诱发的单一浓度的四个基本的味觉刺激（蔗糖，NaCl，HCl和奎宁盐酸盐）进行了四种类型的分析的背景下，提出的四个假设的味道质量编码：跨神经元反应模式、标记线、矩阵模式和跨区域反应模式概念（88个组织学定位的神经元）。跨神经元反应模式的概念假设味觉质量是由跨许多神经元的不同反应幅度编码的。该理论利用跨神经元相关系数作为评价味觉质量编码的度量。在111个皮层神经元中，对四种基本味觉刺激的任何一对的反应幅度之间的跨神经元相关性都非常高，并且是相似的。然而，净反应（减去自发率）的计算结果在不同的味觉刺激之间的正相关性较小，但仍然相似的值。这一发现表明，与低级神经元相比，皮层神经元的跨神经元反应模式在味觉品质之间变得不那么有鉴别力。标记线的概念假设存在可识别的神经元组，并且味觉质量由这些特定神经元组中的活动编码。一些研究人员已经将味觉反应神经元分类为最佳刺激类别，这取决于它们对四种基本刺激中的任何一种的最佳敏感性，例如蔗糖最佳，NaCl最佳，HCl最佳和奎宁最佳神经元;他们建议味觉可以沿着对应于这四种神经元类型的四个定性维度进行分类（即，四条标记线）。本研究表明，每四个最好的刺激神经元的反应有相似的配置文件之间的外周和皮层水平。也就是说，当刺激物按蔗糖、NaCl、HCl和奎宁的顺序沿横坐标沿着排列时，在一个地方存在峰值响应，并且响应从峰值逐渐减小。然而，这样的反应特征不支持标记线理论，因为它们可以在跨神经元模式理论的背景下解释。矩阵模式的概念假设味觉质量是由激活神经元的空间排列矩阵模式编码的。（400字处截断摘要）
The present report was designed to investigate neural coding of taste information in the cerebral cortical taste area of rats. The magnitude and/or type (excitatory, inhibitory, or no-response) of responses of 111 cortical neurons evoked by single concentrations of the four basic taste stimuli (sucrose, NaCl, HCl, and quinine HCl) were subjected to four types of analyses in the context of the four proposed hypotheses of taste-quality coding: across-neuron response-pattern, labeled-line, matrix-pattern, and across-region response-pattern notions (88 histologically located neurons). An across-neuron response-pattern notion assumes that taste quality is coded by differential magnitudes of response across many neurons. This theory utilizes across-neuron correlation coefficients as a metric for the evaluation of taste quality coding. Across-neuron correlations between magnitudes of responses to any pairs of the four basic taste stimuli across 111 cortical neurons were very high and were similar. However, calculations made with net responses (spontaneous rate subtracted) resulted in less positive correlations but still similar values among the various pairs of taste stimuli. This finding suggests that across-neuron response patterns of cortical neurons become less discriminating among taste qualities compared with those of the lower-order neurons. A labeled-line notion assumes that there are identifiable groups of neurons and that taste quality is coded by activity in these particular sets of neurons. Some investigators have classified taste-responsive neurons into best-stimulus categories, depending on their best sensitivity to any one of the four basic stimuli, such as sucrose-best, NaCl-best, HCl-best, and quinine-best neurons; they have suggested that taste can be classified along four qualitative dimensions that correspond to these four neuron types (i.e., four labeled lines). The present study shows that responsiveness of each of the four best-stimulus neurons had similar profiles between peripheral and cortical levels. That is, when the stimuli were arranged along the abscissa in the order of sucrose, NaCl, HCl, and quinine, there is a peak response in one place, and the responses decreased gradually from the peak. However, such response characteristics do not favor the labeled-line theory, since they can be explained in the context of the across-neuron pattern theory. A matrix-pattern notion assumes that taste quality is coded by a spatially arranged matrix pattern of activated neurons.(ABSTRACT TRUNCATED AT 400 WORDS)