INHIBITION BY ANGIOTENSINII OF BARORECEPTOR-EVOKED ACTIVITY IN CARDIAC VAGAL EFFERENT NERVES IN THE DOG
INHIBITION BY ANGIOTENSINII OF BARORECEPTOR-EVOKED ACTIVITY IN CARDIAC VAGAL EFFERENT NERVES IN THE DOG
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DOI：
10.1113/jphysiol.1979.sp012915
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发表时间：
1979-01-01
影响因子：
5.5
通讯作者：
POTTER, EK
中科院分区：
文献类型：
--
作者：
LUMBERS, ER;MCCLOSKEY, DI;POTTER, EK
在静脉注射血管紧张素II和静脉注射苯肾上腺素或主动脉球囊膨胀引起血压升高期间，在从犬颈动脉窦神经解剖的单个压力感受器纤维中记录动作电位。在血管紧张素II和苯肾上腺素或主动脉球囊膨胀引起的血压升高期间，在从其他犬的右颈迷走神经解剖的单个心脏传出纤维中记录动作电位。在任何血压下，使用苯肾上腺素、球囊扩张或血管紧张素II升高压力时，单一颈动脉窦压力感受性纤维的放电频率均无差异。单心脏迷走神经传出纤维的活动增加时，血压升高苯肾上腺素或膨胀的主动脉球囊。当血压升高相当的量，响应于血管紧张素II，迷走神经放电减少（3纤维），从控制水平（4纤维）变化不大，或增加小于它在响应苯肾上腺素（1纤维）。虽然血管紧张素II对压力感受器敏感性没有影响，但它确实抑制由刺激动脉压力感受器诱发的迷走神经放电。
Action potentials were recorded in single baroreceptor fibers dissected from the carotid sinus nerves in dogs during increases in blood pressure caused by i.v. injection of angiotensin II, and by i.v. injection of phenylephrine or inflation of an aortic balloon. Action potentials were recorded in single cardiac efferent fibers dissected from the right cervical vagus nerve in other dogs during increases in blood pressure caused by angiotensin II and by phenylephrine or by inflation of an aortic balloon. There was no difference in the discharge frequency of single carotid sinus baroreceptor fibers at any blood pressure when phenylephrine, balloon inflation or angiotensin II were used to raise the pressure. Activity in single cardiac vagal efferent fibers was increased when blood pressure was increased by phenylephrine or by inflation of an aortic balloon. When blood pressure rose by a comparable amount in response to angiotensin II, vagal firing decreased (3 fibers), was little changed from control levels (4 fibers), or increased less than it did in response to phenylephrine (1 fiber). While angiotensin II has no effect on baroreceptor sensitivity, it does inhibit vagal discharge which is evoked by stimulation of arterial baroreceptors.