Thermoresponsive polymer-encapsulated hollow mesoporous silica nanoparticles and their application in insecticide delivery
Thermoresponsive polymer-encapsulated hollow mesoporous silica nanoparticles and their application in insecticide delivery
复制标题
温敏聚合物封装中空介孔二氧化硅纳米粒子及其在杀虫剂递送中的应用
DOI：
10.1016/j.cej.2019.123169
复制
发表时间：
2020-03-01
影响因子：
15.1
通讯作者：
He, Shun
中科院分区：
文献类型：
--
作者：
Gao, Yunhao;Xiao, Yanan;He, Shun
提高农药功效取决于农药在田间的智能投放，这是将农业化学品的使用减少到最佳水平的基础。本文提出了一种基于农药药效与环境温度关系的温度响应型农药缓释剂THI@HMS@P（NIPAM-MAA）。以中空介孔二氧化硅（HMS）为核，N-异丙基丙烯酰胺-甲基丙烯酸共聚物（P（NIPAM-MAA））为壳，正温度系数杀虫剂噻虫嗪（THI）为模型杀虫剂，采用种子沉淀聚合法制备了THI@HMS@P（NIPAM-MAA）。制备的THI@HMS@P（NIPAM-MAA）能有效保护THI在紫外光照射下的降解，并对水稻叶片表现出较强的粘附性。结果表明，THI@HMS@P（NIPAM-MAA）对褐飞虱的致死率与温度呈正相关，主要受益于温度诱导的释放速率变化。此外，THI@HMS@P（NIPAM-MAA）具有长期生物活性（14 d），对水稻幼苗生长的影响可忽略不计。这种温度响应型释放制剂将来可能会扩展到其他正温度系数农药，从而大大推进智能农药制剂的发展。
Improving pesticide efficacy, which depends on the smart delivery of pesticides in the field, has been the basis for reducing the use of agricultural chemicals to an optimal level. Herein, a temperature-responsive release formulation (THI@HMS@P(NIPAM-MAA)) that can regulate pesticide release based on the relationship between pesticide efficacy and ambient temperature is proposed. The THI@HMS@P(NIPAM-MAA) was prepared by seeded precipitation polymerization, wherein hollow mesoporous silica (HMS) was employed as the core; a commonly used thermoresponsive copolymer, poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAM-MAA)), was used as the outer shell; and a type of positive temperature coefficient insecticide, thiamethoxam (THI), was selected as the model pesticide. The prepared THI@HMS@P(NIPAM-MAA) can effectively protect THI against degradation under UV irradiation and showed strong adhesion to rice leaves. The bioactivity results showed that the mortality of THI@HMS@P(NIPAM-MAA) against Nilaparvata lugens (Stal) (Hemiptera: Delphacidae) was positively correlated with temperature and mainly benefitted from the temperature-induced variation in the release rate. Furthermore, the THI@HMS@P(NIPAM-MAA) possessed long-term bioactivity (14 days) and showed negligible effects on rice seedling growth. This temperature-responsive release formulation may be extended to other positive temperature coefficient pesticides in the future, thus greatly advancing smart pesticide formulation development.