An overview of the immune system
An overview of the immune system
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DOI：
10.1016/s0140-6736(00)04904-7
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发表时间：
2001-06-02
期刊：
影响因子：
168.9
通讯作者：
Cohen, B
中科院分区：
文献类型：
--
作者：
Parkin, J;Cohen, B
我们不断地暴露于吸入、吞咽或栖息在我们皮肤和粘膜上的生物。这些生物体是否侵入并引起疾病，取决于生物体的致病性（其所掌握的毒力因子）和宿主防御机制的完整性。免疫系统是淋巴器官、细胞、体液因子和细胞因子的相互作用网络。免疫系统在宿主防御中的基本功能在它出错时得到最好的说明;活动不足导致严重的免疫缺陷感染和肿瘤，过敏和自身免疫性疾病的过度活动。在这篇综述中，我们介绍了免疫系统在识别、排斥和根除病原体和其他外来分子方面的正常功能。
We are continually exposed to organisms that are inhaled, swallowed, or inhabit our skin and mucous membranes. Whether these organisms penetrate and cause disease is a result of both the pathogenicity of the organism (the virulence factors at its disposal) and the integrity of host defence mechanisms. The immune system is an interactive network of lymphoid organs, cells, humoral factors, and cytokines. The essential function of the,immune system in host defence is best illustrated when it goes wrong; underactivity resulting in the severe infections and tumours of immunodeficiency, overactivity in allergic and autoimmune disease. In this review we have covered the normal function of the immune system in recognising, repelling, and eradicating pathogens and other foreign molecules.