Dissociable contributions of the ventral hippocampus and orbitofrontal cortex to decision-making with a delayed or uncertain outcome
Dissociable contributions of the ventral hippocampus and orbitofrontal cortex to decision-making with a delayed or uncertain outcome
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DOI：
10.1111/ejn.12071
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发表时间：
2013-02-01
影响因子：
3.4
通讯作者：
Chudasama, Yogita
中科院分区：
文献类型：
--
作者：
Abela, Andrew R.;Chudasama, Yogita
在这项研究中，我们研究了风险和延迟如何影响大鼠的决策，以及腹侧海马区(VHC)和眶前叶皮质(OFC)在这两个因素评估中的作用。我们使用触摸屏测试方法，让VHC损伤、OFC损伤和假手术的大鼠在两个决策任务中做出选择。在延迟折扣任务中，老鼠在两种视觉刺激之间进行选择，一种是小的、即时的奖励，另一种是大的、延迟的奖励。在概率折扣任务中，两个刺激分别表示一个小的、确定的奖励或一个大的、不确定的奖励。两个损伤组在两个任务上表现出双重分离。有VHC损伤的大鼠无法忍受延迟，并强烈偏向于小的、即时的回报。然而，在概率折扣任务中，相同的大鼠与假对照组没有区别。在OFC损伤的大鼠中观察到相反的模式；它们在延迟折扣任务中表现正常，但与假手术对照组相比，它们对不确定性的容忍度降低。这些数据支持这样的结论，即VHC和OFC对涉及延迟或不确定结果的决策的贡献不同。这为了解一系列神经学和精神病学患者的神经基础提供了一种手段，这些患者表现出决策和执行功能障碍。
In this study, we examined how risk and delay influence rats' decision-making, and the role of the ventral hippocampus (VHC) and orbitofrontal cortex (OFC) in the valuation of these two factors. We used a touchscreen testing method in which rats with VHC lesions, OFC lesions and sham control surgery made choices in two decision-making tasks. In the delay discounting task, rats chose between two visual stimuli, one of which indicated a small, immediate reward, and the other of which indicated a large, delayed reward. In the probability discounting task, two stimuli indicated, instead, a small, certain reward or a large, uncertain reward. The two lesion groups showed a double dissociation with respect to the two tasks. Rats with VHC lesions were intolerant of delay, and were strongly biased towards the small, immediate reward. However, the same rats were indistinguishable from sham controls in the probability discounting task. The opposite pattern was observed for rats with OFC lesions; they performed normally in the delay discounting task, but showed a reduced tolerance for uncertainty as compared with sham-operated controls. These data support the conclusion that the VHC and OFC contribute differentially to decision-making that involves delayed or uncertain outcomes. This provides a means for understanding the neural basis of a range of neurological and psychiatric patients who show impaired decision-making and executive dysfunction.