Short- and long-term effects of cholinergic modulation on gamma oscillations and response synchronization in the visual cortex
Short- and long-term effects of cholinergic modulation on gamma oscillations and response synchronization in the visual cortex
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DOI：
10.1523/jneurosci.1839-04.2004
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发表时间：
2004-11-17
影响因子：
5.3
通讯作者：
Munk, MHJ
中科院分区：
文献类型：
--
作者：
Rodriguez, R;Kallenbach, U;Munk, MHJ
当对感觉刺激做出反应时，神经元可以在伽马频率范围内进行同步振荡活动。振荡模式和反应的同步性都会随着唤醒和注意力的增加而增强，或者当脑电图通过中脑网状结构的电刺激而激活时都会增强。在这里，我们通过皮质内应用胆碱能拮抗剂表明，伽马振荡和反应同步的增强是由乙酰胆碱和毒蕈碱受体介导的。我们进一步证明，胆碱能激动剂与同步诱导光刺激的共同应用会导致受刺激细胞参与伽马振荡和反应同步的可能性持续增加。这些变化在数十分钟内缓慢发展，然后持续数小时。因此，胆碱能调制在伽马振荡和响应同步的快速、状态依赖性促进以及有利于伽马频率范围内的响应同步的皮质动力学的依赖于使用的长期修改中发挥着至关重要的作用。
Neurons can engage in synchronized oscillatory activity in the gamma-frequency range when responding to sensory stimuli. Both the oscillatory patterning and the synchronization of responses are enhanced with arousal and attention or when the electroencephalogram is activated by electrical stimulation of the mesencephalic reticular formation. Here we show with intracortical application of cholinergic antagonists that the enhancement of gamma oscillations and response synchronization is mediated by acetylcholine and muscarinic receptors. We demonstrate further that coapplication of cholinergic agonists with synchrony-inducing light stimuli causes a lasting increase in the probability that the stimulated cells engage in gamma oscillations and response synchronization. These changes develop slowly over tens of minutes and then persist for many hours. Thus, cholinergic modulation plays a crucial role both in the fast, state-dependent facilitation of gamma oscillations and response synchronization and in use-dependent long-term modifications of cortical dynamics that favor synchronization of responses in the gamma-frequency range.