Cortical reorganization in NT3-treated experimental spinal cord injury: Functional magnetic resonance imaging
Cortical reorganization in NT3-treated experimental spinal cord injury: Functional magnetic resonance imaging
复制标题
DOI：
10.1016/j.expneurol.2006.09.015
复制
发表时间：
2007-03-01
影响因子：
5.3
通讯作者：
Narayana, Ponnada A.
中科院分区：
文献类型：
--
作者：
Ramu, Jaivijay;Bockhorst, Kurt H.;Narayana, Ponnada A.
进行功能性磁共振成像 (fMRI) 研究，以可视化 Neurotropin-3 (NT3) 治疗的实验性脊髓损伤 (SCI) 中持续的大脑可塑性。为了响应前爪的电刺激，接受 NT3 处理的动物表现出大脑结构的广泛激活，包括对侧皮层、丘脑、尾壳核、海马和导水管周围灰质。 fMRI 数据的定量分析表明，相对于盐水处理的对照，NT3 处理的动物的激活体积和中心均发生显着变化。在 NT3 处理的动物中观察到同侧和对侧导水管周围灰质和丘脑的强烈激活。这些研究表明 SCI 动物的大脑正在进行重组。 fMRI 结果还表明 NT3 可能影响伤害感受通路。 (c) 2006 Elsevier Inc. 保留所有权利。
Functional magnetic resonance imaging (fMRI) studies were performed for visualizing ongoing brain plasticity in Neurotrophin-3 (NT3)-treated experimental spinal cord injury (SCI). In response to the electrical stimulation of the forepaw, the NT3-treated animals showed extensive activation of brain structures that included contralateral cortex, thalamus, caudate putamen, hippocampus, and periaqueductal gray. Quantitative analysis of the fMRI data indicated significant changes both in the volume and center of activations in NT3-treated animals relative to saline-treated controls. A strong activation in both ipsi- and contralateral periaqueductal gray and thalamus was observed in NT3-treated animals. These studies indicate ongoing brain reorganization in the SCI animals. The fMRI results also suggest that NT3 may influence nociceptive pathways. (c) 2006 Elsevier Inc. All rights reserved.