Inhibition of Diethylnitrosamine-Induced Hepatocarcinogenesis in Mice by a High Dietary Protein Intake
Inhibition of Diethylnitrosamine-Induced Hepatocarcinogenesis in Mice by a High Dietary Protein Intake
复制标题
高膳食蛋白质摄入抑制二乙基亚硝胺诱导的小鼠肝癌发生
DOI：
10.1080/01635581.2015.1073761
复制
发表时间：
2015-10-03
影响因子：
2.9
通讯作者：
Fu, Huiying
中科院分区：
文献类型：
--
作者：
Shou, Qiyang;Chen, Fangming;Fu, Huiying
流行病学和实验证据支持饮食在多种癌症发展中的关键作用。最近的研究表明，饮食调整可能对肝细胞癌（HCC）高危人群有益。在这项研究中，我们研究了高蛋白（HP； 20%酪蛋白）二乙基亚硝胺（DEN）诱导的肝癌发生的作用。小鼠自由饮水，DEN浓度为30 μg/ml，分别饲喂正常或HP饲料22周。结果显示，与正常饮食的den治疗小鼠相比，食用HP饮食的小鼠死亡率和体重降低，肝酶活性降低。HP消耗还促进了肝脏胶原的积累，减少了增殖性肝细胞和浸润性炎症细胞的数量，降低了炎症因子白介素-1β的表达和核因子κB的活化。这些数据表明，HP饮食可以通过抑制炎症反应来抑制den诱导的肝癌的发生，为临床肝细胞癌患者的饮食管理提供新的证据。
Epidemiological and experimental evidence supports the key role of diet in the development of many types of cancer. Recent studies have suggested that dietary modifications may be beneficial for individuals at high risk for hepatocellular carcinoma (HCC). In this study, we investigated the effect of a high-protein (HP; 20% casein) dietondiethylnitrosamine (DEN)-induced hepatocarcinogenesis. Mice were given free access to water with 30 μg/ml DEN and fed a normal or HP diet for 22 wk. The results showed mice consuming HP diets had reduced mortality rates and body weights and lower hepatic enzyme activity compared to DEN-treated mice on a normal diet. HP consumption also promoted collagen accumulation in the liver, and reduced numbers of proliferating hepatocytes and infiltrating inflammatory cells, as well as decreased expression of inflammatory factor interleukin-1β, and nuclear factor κB activation. These data indicate that HP diets can inhibit DEN-induced hepatocarcinogenesis via suppression of the inflammatory response and provide a new evidence for the dietary management of clinical patients with hepatocellular carcinoma.