A convenient semicarbazide resin for the solid-phase synthesis of peptide ketones and aldehydes
A convenient semicarbazide resin for the solid-phase synthesis of peptide ketones and aldehydes
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DOI：
10.1016/j.tetlet.2005.12.101
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发表时间：
2006-03-06
影响因子：
1.8
通讯作者：
Albericio, F
中科院分区：
文献类型：
--
作者：
Vázquez, J;Albericio, F
使用缩氨基脲树脂固相制备肽酮和醛，在最终产品的纯度和总收率方面都取得了最佳结果。用CDI在室温下活化市售的氨基甲基聚苯乙烯，然后用氨基甲酸叔丁酯处理，制备了该树脂。此外，TNBSA比色法已被用于检查羰基部分与肼基树脂的结合。(c) 2006 Elsevier Ltd.版权所有。
Use of a semicarbazide resin for the solid-phase preparation of peptide ketones and aldehyde led to optimal results in terms of both purity of the final product and overall yield. This resin was prepared without complication by activation of the commercial available aminomethyl polystyrene with CDI at room temperature, followed by treatment with tert-butyl carbazate. Furthermore, the TNBSA colorimetric assay has been adapted for checking the incorporation of the carbonyl moiety onto hydrazine-based resins. (c) 2006 Elsevier Ltd. All rights reserved.