[Advances in integrase regulations of bacteria--A review].
[Advances in integrase regulations of bacteria--A review].
复制标题
DOI：
--
复制
发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Runze Ouyang;Yanyan He;Hai Xu
中科院分区：
文献类型：
--
作者：
Runze Ouyang;Yanyan He;Hai Xu
由于细菌中1类整合子整合酶已被证明与抗菌药物耐药性密切相关，因此我们在本文中总结了一些与整合酶表达相关的调控因素的讨论，如抗生素、碳分解代谢物抑制（cAMP-CRP复合物）、基因盒变异体的启动子（Pc-P2组合）、attC位点、一些核苷酸相关蛋白和可变区的长度。此外，我们还提供整合酶调节机制的知识，以及控制环境中抗菌素耐药性传播的见解。
Because the integrase of class 1 integron in bacteria has been demonstrated closely relative with antimicrobial resistance, we summarize in this review the discussions on some regulation factors with expression of the integrase, such as antibiotics, carbon catabolite repression (cAMP-CRP complex), the promoter of gene cassette variants (Pc-P2 combinations), attC sites, some nucleotide-associated proteins, and the length of variable region. Furthermore, we also provide knowledge of the regulation mechanism of integrase, as well as insight into controlling the dissemination of antimicrobial resistance in the environments.