BIOLOGICAL-ACTIVITY OF "DES-(ASP1,ARG2,VAL3)-ANGIOTENSIN-II IN MAN
BIOLOGICAL-ACTIVITY OF "DES-(ASP1,ARG2,VAL3)-ANGIOTENSIN-II IN MAN
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DOI：
10.1016/0024-3205(83)90079-6
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发表时间：
1983-01-01
期刊：
影响因子：
6.1
通讯作者：
KHOSLA, MC
中科院分区：
文献类型：
--
作者：
KONO, T;OSEKO, F;KHOSLA, MC
当以308-5550 pmol/kg的速率静脉输注des-（Asp 1，Arg 2，Val 3）-血管紧张素II时，对5名正常人和2名Bartter综合征患者进行10-120 min的降压试验，结果表明，正常人血压、血浆肾素活性（PRA）和血浆醛固酮（PA）均无明显变化，最低剂量不能抑制卡托普利引起的PRA升高，但对血压、血浆PRA和PA无明显影响。据报道，在相同的5名正常男性中，（Asp 1，Arg 2）-血管紧张素II在该剂量范围内引起PR降低和PA增加，并且在2220和5550 pmol/kg时引起BP升高。然而，以9000 pmol/kg静脉输注五肽。5例正常人血压明显升高，Bartter综合征患者血压无明显升高。血压恢复到治疗前水平后60分钟停止输注，虽然血管紧张素II，血管紧张素III和des-（Asp 1，Arg 2）-血管紧张素II的升压作用的持续时间在5分钟内，在同一剂量水平的7名受试者没有显示任何显着变化的PRA或PA。以41，480 pmol/kg的速率静脉输注Des-（Asp 1，Arg 2，Val 3，Tyr 4）-血管紧张素II。结果表明，在正常人中，注射100 mg/kg的盐酸利多卡因后，血压、PRA、PA均无明显变化。五肽和可能的四肽在人体内不具有肾素抑制和类固醇生成作用，但五肽确实引起持续时间较长的最小升压作用。
When des-(Asp1, Arg2, Val3)-angiotensin II was infused i.v. at rates of 308-5550 pmol/kg .cntdot. min for 10-120 min into 5 normal men and 2 patients with Bartter''s syndrome, no significant change was observed in blood pressure (BP), plasma renin activity (PRA) or plasma aldosterone (PA), and the lowest dose did not inhibit a captopril-induced increase in PRA in the normal men, although des-(Asp1, Arg2)-angiotensin II was reported in the same 5 normal men to cause a decrease in PR and an increase in PA in this dose range and a rise in BP at 2220 and 5550 pmol/kg .cntdot. min. However, an i.v. infusion of the pentapeptide at 9000 pmol/kg .cntdot. min for 15 min significantly raised BP in the 5 normal men but not in patients with Bartter''s syndrome. BP returned to the pretreatment level 60 min after the cessation of the infusion, although the duration of the pressor actions of angiotensin II, angiotensin III and des-(Asp1, Arg2)-angiotensin II were reported to be within 5 min in man. At the same dose level none of the 7 examined subjects showed any significant change in PRA or PA. Des-(Asp1, Arg2, Val3, Tyr4)-angiotensin II was infused i.v. at a rate of 41,480 pmol/kg .cntdot. min into one of the normal men, but it caused no significant change in BP, PRA or PA. The pentapeptide and probably the tetrapeptide do not possess renin-suppressing and steroidogenic actions in man but the pentapeptide does elicit a minimal pressor action with a prolonged duration.