Prostaglandin synthetase inhibitors in endotoxin or septic shock--a review.
Prostaglandin synthetase inhibitors in endotoxin or septic shock--a review.
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内毒素或感染性休克中的前列腺素合成酶抑制剂——综述。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
J. Fletcher
中科院分区：
文献类型：
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作者：
J. Fletcher
前列腺素显然参与了动物和人类休克的病理生理学。前列腺素合成酶抑制剂是一种非类固醇抗炎药，在过去的二十年里，许多动物研究都使用了前列腺素合成酶抑制剂，特别是在内毒素或感染性休克方面，以确定它们可能有什么作用。该综述显示前列腺素参与内毒素和感染性休克，前列腺素抑制剂可改善包括亚人灵长类在内的多种物种的循环功能和生存。它们发挥其有益作用的确切机制尚不清楚。这些数据表明，前列腺素抑制剂应该在类似休克状态的人体临床试验中进行测试。
Prostaglandins are clearly involved in the pathophysiology of shock in animals and man. Prostaglandin synthetase inhibitors, non-steroidal anti-inflammatory drugs, have been utilized for the past two decades in many animal studies, especially in endotoxin or septic shock, to determine what effects they might have. This review shows that the prostaglandins participate in endotoxin and septic shock and that prostaglandin inhibitors improve circulatory function and survival in a variety of species including the subhuman primate. The exact mechanism by which they exert their beneficial effects remain unknown. The data indicate that prostaglandin inhibitors should be tested in clinical trials in humans in shock-like states.