Altered white matter microstructure in adolescents with major depression: a preliminary study.
Altered white matter microstructure in adolescents with major depression: a preliminary study.
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DOI：
10.1097/00004583-201002000-00011
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发表时间：
2010-02
影响因子：
13.3
通讯作者：
Lim KO
中科院分区：
文献类型：
--
作者：
Cullen KR;Klimes-Dougan B;Muetzel R;Mueller BA;Camchong J;Houri A;Kurma S;Lim KO
重度抑郁症（MDD）经常发生在青少年中，但对青少年抑郁症的神经生物学知之甚少。在成人和儿童人群中的结构神经影像学研究表明，额叶边缘神经网络与MDD的病理生理学有关。扩散张量成像（DTI），测量白色物质（WM）的微观结构，是一种很有前途的工具，用于检查神经连接，以及它们如何在MDD中异常。我们使用两种不同的方法来分析抑郁症青少年（n=14）与健康志愿者（n = 14）的DTI数据。第一，假设驱动的方法是使用概率纤维束描记术来描绘来自膝下前扣带皮层（ACC）的纤维束。青少年抑郁症表现出较低的分数各向异性（FA）在WM束连接膝下ACC杏仁核在右半球。第二，探索性方法是进行FA的体素比较。该分析揭示了10个簇，其中MDD青少年在WM束（包括右侧和左侧钩椎和膝上扣带）内的FA显著低于（未校正）健康组。这些初步的数据支持这一假设，改变WM微结构的额边缘神经通路可能有助于青少年抑郁症的病理生理。
Major Depressive Disorder (MDD) occurs frequently in adolescents, but the neurobiology of depression in youth is poorly understood. Structural neuroimaging studies in both adult and pediatric populations have implicated fronto-limbic neural networks in the pathophysiology of MDD. Diffusion Tensor Imaging (DTI), which measures white matter (WM) microstructure, is a promising tool for examining neural connections and how they may be abnormal in MDD. We used two separate approaches to analyze DTI data in adolescents with MDD (n=14) compared with healthy volunteers (n=14). The first, hypothesis-driven approach was to use probabilistic tractography to delineate tracts arising from the subgenual anterior cingulate cortex (ACC). Adolescents with MDD demonstrated lower fractional anisotropy (FA) in the WM tract connecting subgenual ACC to amygdala in the right hemisphere. The second, exploratory approach was to conduct a voxel-wise comparison of FA. This analysis revealed ten clusters where adolescents with MDD had significantly lower (uncorrected) FA than the healthy group within WM tracts including right and left uncinate and supragenual cingulum. These preliminary data support the hypothesis that altered WM microstructure in fronto-limbic neural pathways may contribute to the pathophysiology of MDD in adolescents.