Does an energy drink modify the effects of alcohol in a maximal effort test?
Does an energy drink modify the effects of alcohol in a maximal effort test?
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DOI：
10.1097/01.alc.0000139822.74414.ec
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发表时间：
2004-09-01
影响因子：
3.2
通讯作者：
Souza-Formigoni, MLO
中科院分区：
文献类型：
--
作者：
Ferreira, SE;de Mello, MT;Souza-Formigoni, MLO
背景：关于酒精和能量饮料（如红牛和类似的饮料，含有咖啡因，牛磺酸，碳水化合物等）结合使用以减少酒精对中枢神经系统的抑制作用的流行报道，但没有进行对照研究。本研究的主要目的是验证酒精以及酒精与能量饮料结合对志愿者在最大努力测试（循环测功仪）中的表现的影响，以及对生理指标（摄氧量、通气量、呼吸交换率、心率和血压）、生化变量（葡萄糖、乳酸、胰岛素、皮质醇、ACTH、多巴胺、去甲肾上腺素和肾上腺素）和血液酒精水平的影响。方法：14名健康受试者完成双盲方案，包括4个阶段：对照组（水）、酒精（1.0 g/kg）、能量饮料（3.57 ml/kg红牛）和酒精+能量饮料，每隔1周。用力试验在药物或对照品摄入后60分钟开始，并在试验后60分钟测量因变量。结果：与对照组和能量饮料组相比，酒精和酒精+能量饮料组的通气阀心率更高。虽然与对照组相比，摄入酒精后的峰值摄氧量降低了5.0%，摄入能量饮料后的峰值摄氧量降低了1.4%，同时摄入能量饮料后的峰值摄氧量降低了2.7%，但没有发现显著差异。与对照组相比，酒精和酒精+能量饮料组的乳酸水平（服药后30分钟、努力试验后30和60分钟）和去甲肾上腺素水平（努力试验后30分钟）更高。结论：摄入酒精+能量饮料后的最大努力测试表现与仅摄入酒精后的表现相似。酒精与酒精+能量饮料在生理生化指标分析上无显著差异。我们的研究结果表明，至少在测试剂量下，能量饮料并没有提高表现或减少急性酒精摄入引起的变化。
Background: There are popular reports on the combined use of alcohol and energy drinks (such as Red Bull(R) and similar beverages, which contain caffeine, taurine, carbohydrates, etc.) to reduce the depressant effects of alcohol on central nervous system, but no controlled studies have been performed. The main purpose of this study was to verify the effects of alcohol, and alcohol combined with energy drink, on the performance of volunteers in a maximal effort test (cycle ergometer) and also on physiological indicators (oxygen uptake, ventilatory threshold, respiratory exchange rate, heart rate, and blood pressure), biochemical variables (glucose, lactate, insulin, cortisol, ACTH, dopamine, noradrenaline, and adrenaline), and blood alcohol levels.Methods: Fourteen healthy subjects completed a double-blind protocol made up of four sessions: control (water), alcohol (1.0 g/kg), energy drink (3.57 ml/kg Red Bull(R)), and alcohol + energy drink, each 1 week apart. The effort test began 60 min after drug or control ingestion, and the dependent variables were measured until 60 min after the test.Results: Heart rate at the ventilatory threshold was higher in the alcohol and alcohol + energy drink sessions in comparison with control and energy drink sessions. Although in comparison to the control session, the peak oxygen uptake was 5.0% smaller after alcohol ingestion, 1.4% smaller after energy drink, and 2.7% smaller after the combined ingestion, no significant differences were detected. Lactate levels (30 min after drug ingestion, 30 and 60 min after the effort test) and noradrenaline levels (30 min after the effort test) were higher in the alcohol and alcohol + energy drink sessions compared with the control session.Conclusions: The performance in the maximal effort test observed after alcohol + energy drink ingestion was similar to that observed after alcohol only. No significant differences between alcohol and alcohol + energy drink were detected in the physiological and biochemical parameters analyzed. Our findings suggest that energy drinks, at least in the tested doses, did not improve performance or reduce alterations induced by acute alcohol ingestion.