Age as a risk factor for severe manifestations and fatal outcome of falciparum malaria in European patients:: Observations from TropNetEurop and SIMPID surveillance data
Age as a risk factor for severe manifestations and fatal outcome of falciparum malaria in European patients:: Observations from TropNetEurop and SIMPID surveillance data
复制标题
DOI：
10.1086/374224
复制
发表时间：
2003-04-15
影响因子：
11.8
通讯作者：
Myrvang, B
中科院分区：
文献类型：
--
作者：
M端hlberger, N;Jelinek, T;Myrvang, B
先前的研究表明，年龄是非免疫患者中严重恶性疟疾的危险因素。本研究的目的是用更大的样本重新评估以前的发现，并找出老年患者的临床结果与年轻患者的差异有多大。校正分析的结果表明，恶性疟疾死亡的风险，经历脑或严重疾病的一般，和住院治疗显着增加每十年的生活。老年患者的病死率几乎是年轻患者的6倍，老年患者脑并发症的发生率是年轻患者的3倍。抗疟药物预防与较低的病死率和较低的脑并发症发生率显著相关。女性比男性更容易患脑部并发症。我们的研究提供的证据表明，恶性疟疾在老年患者中更为严重，并表明临床监测网络能够为罕见事件或疾病的调查提供高质量的数据。
Previous studies have indicated that age is a risk factor for severe falciparum malaria in nonimmune patients. The objectives of this study were to reevaluate previous findings with a larger sample and to find out how strongly clinical outcomes for elderly patients differ from those for younger patients. Results of adjusted analyses indicated that the risks of death due to falciparum malaria, of experiencing cerebral or severe disease in general, and of hospitalization increased significantly with each decade of life. The case-fatality rate was almost 6 times greater among elderly patients than among younger patients, and cerebral complications occurred 3 times more often among elderly patients. Antimalarial chemoprophylaxis was significantly associated with a lower case-fatality rate and a lower frequency of cerebral complications. Women were more susceptible to cerebral complications than were men. Our study provides evidence that falciparum malaria is more serious in older patients and demonstrates that clinical surveillance networks are capable of providing quality data for investigation of rare events or diseases.