Transposition of the oncogene c-ets-1 in a t(11;19)(q23;p13) cell line transient during clonal evolution of blast crisis chronic myeloid leukemia.
Transposition of the oncogene c-ets-1 in a t(11;19)(q23;p13) cell line transient during clonal evolution of blast crisis chronic myeloid leukemia.
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急变慢性粒细胞白血病克隆进化过程中，t(11;19)(q23;p13) 细胞系中癌基因 c-ets-1 的转位短暂。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Fitzgerald Ph
中科院分区：
文献类型：
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作者：
Morris Cm;Whitham Se;Fitzgerald Ph
1例Ph阴性慢性粒细胞白血病患者在进入急变期时表现出活跃的核型演变。一个细胞系，其中占主导地位的一个短暂的加速骨髓相，其特征是t（11;19）（q23;p13）。染色体原位杂交显示癌基因c-ets-1从der（11 q-）移动到der（19 p+）。19 p13的断裂点位于人胰岛素受体基因座（INSR）附近。Southern印迹分析未发现c-ets和INSR基因重排。髓系细胞系由细胞形态和免疫球蛋白JH基因重排缺失指示，并由生殖系bcr-3'基因缺失支持。涉及11 q23的染色体重排和c-ets-1的移动是单核细胞和淋巴细胞白血病的特征，以前在慢性粒细胞白血病的髓系急变中没有报道。
A patient with Ph-negative chronic myeloid leukemia showed active karyotypic evolution when he entered blast crisis. One cell line, which predominated briefly in an accelerated myeloid phase, was characterized by the t(11;19)(q23;p13). Chromosome in situ hybridization demonstrated movement of the oncogene c-ets-1 from the der (11q-) to the der (19p+). The breakpoint at 19p13 was in the vicinity of the human insulin receptor gene locus (INSR). No rearrangements of the c-ets and INSR genes were found in Southern blot analyses. Myeloid lineage was indicated by cell morphology and absence of immunoglobulin JH gene rearrangement and was supported by loss of the germ line bcr-3' gene. Chromosome rearrangements involving 11q23 and movement of c-ets-1 characterize monocytic and lymphoid leukemias and have not previously been reported in myeloid blast crisis of chronic myeloid leukemia.