ON THE USE OF IBOTENIC ACID TO LESION SELECTIVELY DIFFERENT COMPONENTS OF THE HIPPOCAMPAL-FORMATION
ON THE USE OF IBOTENIC ACID TO LESION SELECTIVELY DIFFERENT COMPONENTS OF THE HIPPOCAMPAL-FORMATION
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DOI：
10.1016/0165-0270(89)90149-0
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发表时间：
1989-09-01
影响因子：
3
通讯作者：
JARRARD, LE
中科院分区：
文献类型：
--
作者：
JARRARD, LE
描述了使用多次注射少量鹅膏蕈氨酸（IBO）损伤海马结构（海马，下托）的两个组成部分的程序。所产生的细胞损失比用常规技术可以获得的细胞损失更具选择性和有限性。因此，与对邻近区域的损伤、通道纤维和对脉管系统的损伤相关的问题被最小化。行为实验的结果表明，海马的IBO损伤的影响是更微妙的比那些发现与传统的损伤技术。使用多次注射少量神经毒素的一般方法可用于选择性地损害海马结构的其他组成部分。
Procedures are described for lesioning two components of the hippocampal formation (hippocampus, subiculum) using multiple injections of small amounts of ibotenic acid (IBO). The resulting loss of cells is more selective and limited than can be obtained with conventional techniques. Thus, problems associated with damage to adjacent areas, fibers-of-passage, and damage to the vasculature are minimized. The results of behavioral experiments indicate that the effects of IBO lesions of the hippocampus are more subtle than those found with conventional lesion techniques. The general approach of using multiple injections of small amounts of neurotoxins can be used to selectively lesion other components of the hippocampal formation.