Prevalence and antimicrobial susceptibility pattern of Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi among febrile patients at Karamara Hospital, Jigjiga, eastern Ethiopia
Prevalence and antimicrobial susceptibility pattern of Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi among febrile patients at Karamara Hospital, Jigjiga, eastern Ethiopia
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DOI：
10.1177/2050312119837854
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发表时间：
2019-03-15
影响因子：
2.3
通讯作者：
Teklemariam, Zelalem
中科院分区：
文献类型：
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作者：
Admassu, Dawit;Egata, Gudina;Teklemariam, Zelalem
目的：本研究的目的是确定伤寒沙门氏菌和副伤寒沙门氏菌在埃塞俄比亚东部吉吉加Karamara医院发热患者中的患病率和抗菌药物敏感性模式。研究方法：2016年2月15日至3月20日，在Karamara医院的203例疑似肠热病（伤寒沙门氏菌和副伤寒沙门氏菌）发热患者中进行了一项横断面研究。采集静脉血，进行培养和生化检查。采用改良Kirby-Bauer纸片扩散法对每株分离株进行药敏试验。结果：伤寒沙门氏菌和副伤寒沙门氏菌的总患病率为11%。伤寒沙门菌的检出率（7%）高于副伤寒沙门菌（4%）。在31-45岁的研究参与者中，有肠道发热病史的几率较高。伤寒沙门菌对四环素、庆大霉素和头孢曲松的敏感率分别为78.6%、64.3%和64%，而副伤寒沙门菌对四环素、庆大霉素和环丙沙星的敏感率分别为100%、100%和62.5%。所有分离株均对氨苄青霉素和氯霉素耐药。大多数菌株存在多重耐药。结论：在这项研究中观察到肠热病的高患病率和对最常用抗菌药物的耐药性。有肠道感染史的老年人更易发生肠热病。应提供有关肠热病传播、预防和抗菌药物使用的健康信息。伤寒的治疗应得到研究地区抗菌药物敏感性试验的支持。
Objective: The aim of this study was to determine the prevalence and antimicrobial susceptibility pattern of Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi among febrile patients at Karamara Hospital, Jigjiga, eastern Ethiopia. Methods: A cross-sectional study was conducted among 203 febrile patients presumptive of enteric fever (Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi) at Karamara Hospital from 15 February to 20 March 2016. Venous blood was collected, cultured, and biochemical tests were performed. Antimicrobial susceptibility testing was performed for each isolate using modified Kirby-Bauer disk diffusion technique. Results: The overall prevalence of enteric fever (Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi) was 11%. The prevalence of Salmonella enterica serovar Typhi (7%) was higher than Salmonella enterica serovar Paratyphi (4%). The odds of having enteric fever were higher among the study participants aged 31-45 years and with previous history of enteric fever. Most of the Salmonella enterica serovar Typhi isolates were sensitive to tetracycline (78.6%), gentamycin (64.3%), and ceftriaxone (64%), while most of the isolates of Salmonella enterica serovar Paratyphi were sensitive to tetracycline (100%), gentamycin (100%), and ciprofloxacin (62.5%). All the isolates were resistant to ampicillin and chloramphenicol. Multidrug resistances were found among most of the isolates. Conclusion: A high prevalence of enteric fever and drug resistance to most commonly prescribed antimicrobials were observed in this study. Those of old age with previous history of enteric infection were more affected by enteric fever. Health information should be given about the transmission, prevention of enteric fever, and antimicrobial use. The treatment of enteric fever should be supported by antimicrobial susceptibility tests in the study areas.