The PASTA domain:: a β-lactam-binding domain
The PASTA domain:: a β-lactam-binding domain
复制标题
DOI：
10.1016/s0968-0004(02)02164-3
复制
发表时间：
2002-09-01
影响因子：
13.8
通讯作者：
Bateman, A
中科院分区：
文献类型：
--
作者：
Yeats, C;Finn, RD;Bateman, A
PASTA结构域（青霉素结合蛋白和丝氨酸/苏氨酸激酶相关结构域）存在于一系列病原体的高分子量青霉素结合蛋白和真核生物样丝氨酸/苏氨酸激酶中。我们描述了这个以前未表征的结构域，并推断它与β-内酰胺抗生素及其肽聚糖类似物结合。我们假设PknB样激酶是细胞壁生物合成的关键调节因子。这些酶的基本功能表明β-内酰胺抗生素作用的另一途径。
The PASTA domain (for penicillin-binding protein and serine/threonine kinase associated domain) is found in the high molecular weight penicillin-binding proteins and eukaryotic-like serine/threonine kinases of a range of pathogens. We describe this previously uncharacterized domain and infer that it binds beta-lactam antibiotics and their peptidoglycan analogues. We postulate that PknB-like kinases are key regulators of cell-wall biosynthesis. The essential function of these enzymes suggests an additional pathway for the action of beta-lactam antibiotics.