Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs.
Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs.
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环加氧酶抑制剂可预防乙氯维诺引起的大鼠和兔子肺部损伤。
DOI：
10.1152/jappl.1991.71.1.43
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Dahms,TE
中科院分区：
文献类型：
--
作者：
Zanaboni,PB;Bradley,JD;Webster,RO;Dahms,TE
本文研究了三种化学成分不同的环氧合酶抑制剂对乙氯乙烯(ECV)所致大鼠肺损伤和兔肺血灌流损伤的影响。ECV使大鼠肺微血管液滤过系数(KF)增加3倍以上，兔肺增加2倍以上。在大鼠实验中，ECV导致肺血管阻力(PVR)和微血管压(MVP)增加，双阻断技术(PDO)测得的肺血管阻力(PVR)和微血管压(MVP)均高于溶剂对照组。在兔实验中，ECV对PVR和PDO无明显影响。用环氧合酶抑制剂吲哚美辛、布洛芬和甲氯芬酸酯预处理可阻止大鼠和兔肺制剂中微血管通透性的增加。环氧合酶抑制剂也能抑制ECV诱导的大鼠肺PVR和PDO增加，但对兔肺PVR和PDO无影响。这些结果表明，花生四烯酸代谢的环氧合酶产物在ECV诱导的大鼠和兔肺的KF增加中起中介作用。
The effect of three chemically dissimilar cyclooxygenase inhibitors on ethchlorvynol-(ECV) induced acute lung injury was studied in isolated buffer-perfused rat and blood-perfused rabbit lungs. ECV caused the microvascular fluid filtration coefficient (Kf) to increase by greater than threefold in the rat lungs and twofold in the rabbit lungs. ECV caused increased pulmonary vascular resistance (PVR) and microvascular pressure measured by the double occlusion technique (Pdo) compared with the vehicle control group in the rat experiments. However, ECV had no effect on PVR or Pdo in the rabbit experiments. Pretreatment with the cyclooxygenase inhibitors indomethacin, ibuprofen, and meclofenamate prevented the increase in microvascular permeability in both the rat and rabbit lung preparations. The cyclooxygenase inhibitors also prevented the ECV-induced PVR and Pdo increases in the rat lungs but had no effect on PVR or Pdo in the rabbit lungs. These results indicate that cyclooxygenase products of arachidonate metabolism mediate the ECV-induced Kf increase in both isolated rat and rabbit lungs.