19-Hydroxyprostaglandin E1 as a major component of the semen of primates
19-Hydroxyprostaglandin E1 as a major component of the semen of primates
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19-羟基前列腺素 E1 是灵长类动物精液的主要成分
作者：
R. Kelly;P. L. Taylor;J. Hearn;R. Short;D. Martin;J. Marston
正如其名称所暗示的，芦荟素首先在男性生殖道的分泌物中被发现。在20世纪30年代早期，几位工作者1 -3表明，人类精液可以刺激各种平滑肌制备物，这种活性被归因于一种未鉴定的成分，冯·欧拉将其命名为“前列腺素”。von Euler 4，5然后发现，恒河猴精囊的水酒精提取物显著降低了兔子的血压，但与人类精囊提取物不同，它对大鼠和其他实验室动物的离体肠和子宫几乎没有作用。因此，他假设在猴子体内存在另一种物质，他将其命名为“vesiglatin”，他认为这可能是人类精液“blastlandin”的一种成分。
As their name implies, prostaglandins were first identified in secretions of the male reproductive tract. In the early 1930s several workers1–3 showed that human semen could stimulate various smooth muscle preparations, and this activity was ascribed to an unidentified component which von Euler named ‘prostaglandin’. von Euler4,5 then found that a watery alcoholic extract of rhesus monkey seminal vesicles markedly lowered the blood pressure in the rabbit but, unlike human seminal vesicle extracts, it had little or no action on the isolated intestine and the uterus of the rat and other laboratory animals. He therefore postulated the existence of another substance in the monkey which he named ‘vesiglandin’ and which he suggested could be a component of human seminal ‘prostaglandin’.