Insomnia with objective short sleep duration is associated with longer duration of insomnia in the Freiburg Insomnia Cohort compared to insomnia with normal sleep duration, but not with hypertension
Insomnia with objective short sleep duration is associated with longer duration of insomnia in the Freiburg Insomnia Cohort compared to insomnia with normal sleep duration, but not with hypertension
复制标题
DOI：
10.1371/journal.pone.0180339
复制
发表时间：
2017-07-26
期刊：
影响因子：
3.7
通讯作者：
Spiegelhalder, Kai
中科院分区：
文献类型：
--
作者：
Johann, Anna F.;Hertenstein, Elisabeth;Spiegelhalder, Kai
研究目的：复制客观睡眠时间短的失眠症与高血压、2型糖尿病和失眠持续时间的关系。设计了一项回溯性病例对照研究。研究对象为328例符合DSM-IV标准的原发性失眠症患者(男性125例，女性203例，年龄44.3±12.2岁)。研究对象为328例符合DSM-IV标准的原发性失眠症患者(男性125例，女性203例，年龄44.3±12.2岁)。N/AM调查所有参与者都进行了多导睡眠图、血压测量和空腹常规实验。结果与正常睡眠时间(>；)相比，实验室第一晚睡眠时间短(&1；6小时)的失眠症患者具有更长的失眠持续时间。=6小时)在实验室睡眠的第一个晚上。在任何一个晚上被归类为短睡者的失眠症患者患高血压的可能性并不更大(收缩压=140毫米汞，舒张压=90毫米汞，或先前已确诊的)。数据分析表明，客观睡眠时间较短的失眠患者患2型糖尿病的可能性并不大(空腹血糖水平=126 mg/dl，或有既往诊断)。然而，糖尿病分析只基于非常少量的糖尿病病例。结论失眠持续时间的研究结果支持失眠的两个不同亚组的概念，即有失眠和无失眠，客观上确定了短睡眠的持续时间。然而，我们的数据挑战了之前的发现，即睡眠时间短的失眠患者更有可能患有高血压。
Study objectivesTo replicate the association between insomnia with objective short sleep duration and hypertension, type 2 diabetes and duration of insomnia.DesignRetrospective case-control study.SettingDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg.Participants328 patients with primary insomnia classified according to DSM-IV criteria (125 males, 203 females, 44.3 +/- 12.2 years).InterventionsN/AMeasurementsAll participants were investigated using polysomnography, blood pressure measurements, and fasting routine laboratory.ResultsInsomnia patients with short sleep duration (< 6 hours) in the first night of laboratory sleep presented with a longer duration of insomnia compared to those with normal sleep duration (>= 6 hours) in the first night of laboratory sleep. Insomnia patients who were categorised as short sleepers in either night were not more likely to suffer from hypertension (systolic blood pressure of >= 140 mm Hg, diastolic blood pressure of >= 90 mm Hg, or a previously established diagnosis). Data analysis showed that insomnia patients with objective short sleep duration were not more likely to suffer from type 2 diabetes (fasting plasma glucose level of >= 126 mg/dl, or a previously established diagnosis). However, the diabetes analysis was only based on a very small number of diabetes cases. As a new finding, insomnia patients who were categorised as short sleepers in either night presented with increases in liver enzyme levels.ConclusionsThe finding on insomnia duration supports the concept of two distinct sub-groups of insomnia, namely insomnia with, and without, objectively determined short sleep duration. However, our data challenges previous findings that insomnia patients with short sleep duration are more likely to suffer from hypertension.