Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity.
Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity.
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DOI：
10.3389/fendo.2020.00654
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发表时间：
2020
影响因子：
5.2
通讯作者：
Dranoff J
中科院分区：
文献类型：
--
作者：
Tas E;Bai S;Ou X;Mercer K;Lin H;Mansfield K;Buchmann R;Diaz EC;Oden J;Børsheim E;Adams SH;Dranoff J
背景资料：迫切需要有效和非侵入性的生物标志物来跟踪非酒精性脂肪性肝病（NAFLD）风险儿童的肝内甘油三酯（IHTG），因为标准护理参考工具，肝活检和磁共振成像（MRI），对于监测病程是不切实际的。目的：我们的目的是通过MRI评估肥胖儿童血清成纤维细胞生长因子（FGF）-21与脂联素比值（FAR）和IHTG之间的关系。研究方法：在两个时间点（基线，6个月）测量参加临床减肥计划的肥胖儿童的血清FGF 21和脂联素水平以及IHTG。使用多元线性回归模型检查最终访视时FAR和IHTG百分比变化之间的相关性。结果：基线时，NAFLD受试者的FAR（n = 23，35.8 ± 41.9 pg/ng）高于非NAFLD受试者（n = 35，19.8 ± 13.7 pg/ng; p = 0.042）。48例受试者完成了两次访视，并被分为IHTG降低（较基线降低≥1%）、无变化（在±1%变化范围内）和增加（较基线增加≥1%）组。在6个月时，三组之间FAR的百分比变化不同（p = 0.005）。多元线性回归显示，在基线时患有NAFLD的性别和青春期阶段相似的受试者中，FAR的百分比变化与最终肝脏脂肪百分比之间呈正相关（斜率系数6.18，95%CI 1.90-10.47，P = 0.007），但在没有NAFLD的受试者中则不相关。结论：在基线NAFLD儿童中，FAR增加百分比的较高值与6个月时IHTG百分比值的较高水平呈正相关。FAR可能是监测NAFLD儿童IHTG变化的潜在生物标志物。
Background: There is a pressing need for effective and non-invasive biomarkers to track intrahepatic triglyceride (IHTG) in children at-risk for non-alcoholic fatty liver disease (NAFLD), as standard-of-care reference tools, liver biopsy and magnetic resonance imaging (MRI), are impractical to monitor the course disease. Objective: We aimed to examine the association between serum fibroblast growth factor (FGF)-21 to adiponectin ratio (FAR) and IHTG as assessed by MRI in children with obesity. Methods: Serum FGF21 and adiponectin levels and IHTG were measured at two time points (baseline, 6 months) in obese children enrolled in a clinical weight loss program. The association between percent change in FAR and IHTG at final visit was examined using a multiple linear regression model. Results: At baseline, FAR was higher in the subjects with NAFLD (n = 23, 35.8 ± 41.9 pg/ng) than without NAFLD (n = 35, 19.8 ± 13.7 pg/ng; p = 0.042). Forty-eight subjects completed both visits and were divided into IHTG loss (≥1% reduction than baseline), no change (within ±1% change), and gain (≥1% increase than baseline) groups. At 6 months, the percent change in FAR was different among the three groups (p = 0.005). Multiple linear regression showed a positive relationship between percent change in FAR and the final liver fat percent in sex and pubertal stage-similar subjects with NAFLD at baseline (slope coefficient 6.18, 95% CI 1.90–10.47, P = 0.007), but not in those without NAFLD. Conclusions: Higher value in percent increase in FAR is positively associated with higher level of IHTG percent value at 6 months in children with baseline NAFLD. FAR could be a potential biomarker to monitor the changes in IHTG in children with NAFLD.
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影响因子：
8
作者：
Luukkonen, Panu K.;Nick, Auli;Yki-Javinen, Hannele
通讯作者：
Yki-Javinen, Hannele
影响因子：
12.6
作者：
Kim, Donghee;Kim, W. Ray
通讯作者：
Kim, W. Ray
影响因子：
7.1
作者：
Kliewer, Steven A.;Mangelsdorf, David J.
通讯作者：
Mangelsdorf, David J.
影响因子：
29
作者：
Holland WL;Adams AC;Brozinick JT;Bui HH;Miyauchi Y;Kusminski CM;Bauer SM;Wade M;Singhal E;Cheng CC;Volk K;Kuo MS;Gordillo R;Kharitonenkov A;Scherer PE
通讯作者：
Scherer PE
影响因子：
11.1
作者：
Dongiovanni P;Stender S;Pietrelli A;Mancina RM;Cespiati A;Petta S;Pelusi S;Pingitore P;Badiali S;Maggioni M;Mannisto V;Grimaudo S;Pipitone RM;Pihlajamaki J;Craxi A;Taube M;Carlsson LMS;Fargion S;Romeo S;Kozlitina J;Valenti L
通讯作者：
Valenti L