Tenuigenin Attenuates α‐Synuclein‐Induced Cytotoxicity by Down‐Regulating Polo‐Like Kinase 3
Tenuigenin Attenuates α‐Synuclein‐Induced Cytotoxicity by Down‐Regulating Polo‐Like Kinase 3
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DOI：
10.1111/cns.12124
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发表时间：
2013-09
影响因子：
5.5
通讯作者：
Jinxia Zhou;Hao-Bo Zhang;Yue Huang;Yi He;Yan Zheng;John P. Anderson;W. Gai;Zhijuan Liang;Yong Wang;Xingmei Ren;Qi Wang;Xiao-Li Gong;Jian Yang;Xuan Wang;G. Halliday;Xiao-min Wang
中科院分区：
文献类型：
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作者：
Jinxia Zhou;Hao-Bo Zhang;Yue Huang;Yi He;Yan Zheng;John P. Anderson;W. Gai;Zhijuan Liang;Yong Wang;Xingmei Ren;Qi Wang;Xiao-Li Gong;Jian Yang;Xuan Wang;G. Halliday;Xiao-min Wang
Tenuigenin (Ten) is a Chinese herbal extract with antioxidative and antiinflammatory effects on toxin‐induced cell models of Parkinson's disease (PD); however, its effects on α‐synuclein toxicity‐based PD models remain unknown. α‐synuclein hyperphosphorylation is a key event in PD pathogenesis and potential target of therapeutic interventions. We tested whether Ten alleviates α‐synuclein‐induced cytotoxicity via reducing kinases that phosphorylate α‐synuclein.
